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International Conference on
Obesity and Weight Loss

November 6-8, 2017 | Barcelona, Spain

Program Schedule

  • Keynote Speaker

    Time:

    Title

    Title: Obesity and Heart Failure the two Pandemics of our Days

    E.Radzishevsky
    Heart Failure Center, Israel
    Biography
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    Biography

    Eugeny Radzishevsky is a Head of Herat Failure Center, Clalit Health Services, IL. He completed academic Degree MD, 1990-1996 University of Medicine Kharkov, Ukraine. Professional Experience in 1996 -2011-Cardiology training, Bnai Zion Medical Center & Faculty of Medicine, Technion, Haifa, IL In 2011 worked as a Senior Cardiologist, Dept. of Cardiology, Bnai-Zion Medical Center.



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    Sessions:
    Cardiovascular Diseases, Pulmonary Function, Allergy & Immunity, Obesity and weight management & Endocrinal Disorders and Diabetes

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    Title: Genetics and epigenetics markers of adiposity toward precision medicine

    Amelia Marti
    University of Navarra
    Spain

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    Biography

    Amelia Marti
    University of Navarra
    Spain

    Professor in Human Physiology, University of Navarra, Pamplona (Spain). Doctorate with Honors. Working abroad: Baylor College of Medicine, Harvard Medical School, University of Marburg and Tufts University. 15 doctoral theses supervised and participation in over 22 research projects. Her research in the field of nutrition and obesity, with more than 229 scientific publications and H factor = 37 (Web of Science). Prof. Marti has received the Silver Medal of the British Society for Nutrition, the Merck & Daphne Award, the award of the NAOS Spanish Strategy, the European Prize for the Best Doctoral Thesis supervised in Obesity. Expert in the Board of the Spanish Society for Obesity.



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    Abstract

    Amelia Marti
    University of Navarra
    Spain

    Advances in genetics and epigenetics have resulted in the identification of about 100 and 200 loci respectively, related to human adiposity. FTO gene variants are the most replicated and showed the highest statistical significance. However, despite these advances, the combined effect of genome identified so far account for about 5% of the inherited contribution to obesity risk (40 to 70). These statistics confirm the complex nature of obesity and the need to identify additional factors including (epi)genetic markers and also their interactions with environmental factors. The OMICs technologies could help to study genetic predisposition (genome), and changes in epigenetics (epigenome), gene expression (transcriptome), proteins (proteome), and metabolites (metabolome) to further improve prevention, diagnosis and treatment of obesity and related complications. Here I will present some examples of the importance of genetic and epigenetic markers when studying the response to nutritional interventions such as: the PREDIMED Navarra study (based on a Mediterranean diet pattern in high cardiovascular risk subjects), and the EVASYON study (a weight loss program for Spanish obese adolescents).

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    Title: The Effect of a Structured Exercise Program on Obese African American Participants Physical and Psychological Health

    Lakina Moseley
    Wayne State University, USA

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    Biography

    Lakina Moseley
    Wayne State University, USA

    Lakina Moseley, DHEd, is an adjunct professor at Wayne State University for the Division of Kinesiology, Health and Sport Studies. Her areas of expertise are exercise and nutrition, physical education, health education, and aquatics. Her research interests are obesity prevention and treatment, physical activity and nutrition behavioral intervention, and exercise motivation and adherence. Dr. Moseley is also the owner of Destination Fitness, which provides individualized exercise programs to her clients. She holds a bachelors in kinesiology and a masters in the art of teaching from Wayne State University. She also holds a doctorate in health education from A.T. Still University



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    Abstract

    Lakina Moseley
    Wayne State University, USA

    Obesity is a global epidemic affecting millions of people. It leads to a myriad of health problems with the most serious being death. By increasing physical activity, obesity can be reversed and or prevented. The purpose of this study was to determine how having a structured exercise program affects overall physical activity and psychological health. Specifically, this investigation examined how body image, self efficacy and motivation would affect overall physical activity. Using a mixed-method design, subjects were evaluated using pre and post intervention surveys on physical activity, self-efficacy, body esteem and motivation. Results showed that there was a significant difference in self efficacy, motivation and male body esteem when comparing their post-intervention scores to their pre-intervention scores. However, there was no significant difference in the three phases of overall physical activity or female body esteem. Although there was no significant difference in overall physical activity, the results show it was trending in a positive direction. The small sample size, study duration, physical activity assessment may have influenced the results. Even though there was no significant difference in overall physical activity or female body esteem, a structured exercise program appears to be promising tool for increasing overall physical activity and psychological health. Keywords: Body esteem, motivation, self-efficacy, physical activity, structured exercise program, obesity, African American, psychological health, Health Belief Model, Logic Model

    Time:

    Title: Balanced gut probiotics: target gears for diabetes therapy

    Nditange Shigwedha
    FERTIPAQ Shanghai, China

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    Biography

    Nditange Shigwedha
    FERTIPAQ Shanghai, China

    Nditange Shigwedha is a Senior R&D Scientist at FERTIPAQ Shanghai. He studied BSc. Agriculture at the University of Namibia; both MSc. Food Science and PhD. Environmental Engineering at Jiangnan University. From 2007-2013, he has taught as a Senior Lecturer at the University of Namibia and afterward sabbatical for his Postdoctoral research in a Food microbiology laboratory at Harbin Institute of Technology. In 2016, he has held to the position of a Head of the R&D department at CPS China in Suzhou. Formerly also served as HOD: Food Science & Technology and occasionally acted as a Faculty Dean of Agriculture & Natural Resources at the University of Namibia 2008-2012.



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    Abstract

    Nditange Shigwedha
    FERTIPAQ Shanghai, China

    The human gastrointestinal tract contains atrillions number of microorganisms. Although this tract is relatively dominated by a highly diverse number of probiotics at subspecies levels, there appears to be microbial disparity at some of the divisions of the GI tract. The genome size of the stablemicrobial structure, collectively termed as microbiome, may providehumans with metabolic and genetic attributes pertinent to the maintenance of holistic homeostasis. These days, accumulating evidence reveals that gut microbiota in the humans body may play a significant role in the development of obesity, metabolic syndromes such as diabetes, cardiovascular disease, andmany other current critical endocrinal or metabolic disorders. In this paper, the mechanisms of actions by which the gut microbiota take part in the holistic activitieswithin the host are explained. The results indicated that balanced probiotics mighthave a positive impact on the development of diabetes, together withlow-grade inflammations, lipid metabolism, energy harvesting, bowel function of the intestinal barrier, as well as bile acid metabolism. Thus, balanced probiotics at each division of GI tract and total gut microbiota in the host could be a naturalbiological factor to modulate diabetes if scientifically synchronized. Keywords: Gut microbiota; Probiotics; Diabetes; Obesity; Metabolism

    Time:

    Title: Personalized weight-loss diet interventions

    Lu Qi
    Tufts University, USA

    Biography
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    Biography

    Lu Qi
    Tufts University, USA

    Dr. Qi obtained a medical degree in China and PhD at Tufts University in the United States. He is now HCA Regents Distinguished Chair and Professor in Tulane University and Adjunct Professor at Harvard T.H Chan School of Public Health. He has published more than 250 scientific publications and edited a textbook.



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    Lu Qi
    Tufts University, USA

    Obesity has become epidemic worldwide. Diet interventions have been widely accepted in prevention and treatment of obesity; however, considerable individual variability has long been noted in response to diet interventions, which is likely due to modifications of genetic susceptibility. In large prospective studies, we have identified dietary intakes of sugar sweetened beverage and fried amplified genetic effects on body weight and obesity. In randomized clinical trials, we demonstrated that genetic variants related to obesity, insulin resistance and obesity significantly interacted with diet interventions in relation to long-term weight loss, and changes in cardiometabolic risk factors. In addtion, we found that gentic variations determining preference to macronutrients modified effects of carbohydrate intakes on weight loss. Our data provide supportive evidence for precision obesity management through diet modifications.

    Time:

    Title: CTRP 12 (Adipoline) reduction in obese subjects would be responsible for their dyslipidemia risk

    Sattar Gorgani
    AJA University, Iran

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    Biography

    Sattar Gorgani
    AJA University, Iran

    Sattar Gorgani-Firuzjaee was born 1980 in Babol of IRAN. I studied clinical biochemistry in Tehran University of medical sciences 2015. At now He works as faculty member of AJA University of medical sciences in Tehran.



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    Sattar Gorgani
    AJA University, Iran

    Background and aim In obesity, hypertrophied adipocytes via imbalanced secretion of adipokines lead to dyslipidemia and changed proinflammatory and antiinflammatory adipokines secretion. According to the adipokines expression in various pathological conditions like obesity, diabetes, atherosclerosis and inflammatory diseases, so adipokines as biomarkers are very important in diagnosis and managment. CTRP 12 (adipoline) as a member of CTRP family, abundantly expressed in adipose tissue. Both contineus endurance tarining and high intensity interval training mainly prescribed for managment of metabolic complication such as obesity and obesity related disease. This work directly evidenced the effect of exercise intervention on adipoline in obes subjects and responsible molecular mechanism of CTRP 12 lipid lowering effect. Methods This study investigated adipoline and lipid profil in obese subjects and age, sex matched normal wight population. Then analyzed adipoline and lipid profile in regular exercise trained and non regular exercise trained subjects. To prove importance of sport intrvention designed 2 month endurance sport intervention trial in 18 volentier men (25-45 year old). In addition the effect of sport intervention on adipoline level in high fat induced animal model and effect of adipoline modulation on denovo lipogenesis in HepG2 cells was investigated. Results The results show lower CTRP 12 and higher lipid profile in obes and metabolic syndrom subjects, and this finding reversed in regular exercisae trained subjects. Importantly sport intervention traial confirmrd the results of case-control study. In addition our animal study demonstrat that sport intrvention, specially HIIT program induces adipoline level and reduces lipid profil. Importantly CTRP 12 gene overexpresion by retrovirus system proved animal finding and reduced denovo lipogenesis either at total lipid content or key lipogenic gene mRNA and protein expression. Conclusion The results showed lowerlevel of CTRP-12 in obes subjects could be responsible molecular mechanim of higher lipid profile and dyslipidemia risk. Long life programed physical activity specially HIIT recommened to manage most of metabolic disease.

    Time:

    Title: Anti-obesity effect of Physagulin-F isolated from Physalis angulatafruits in lean rats fed a high fat diet

    Estari Mamidala
    Kakatiya University, India

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    Biography

    Estari Mamidala
    Kakatiya University, India

    Dr,EstariMamidala completed his under graduation and post-graduation from Kakatiya University. He did Ph.D in Zoology Department, Kakatiya University, India. He awarded DBT rapid grant young investigator award. After the completing of his Ph.D he was selected as Fast Track Young Principal Investigator from DST, New Delhi. Now he is doing post-doctoral research. He published more than 15 research publications in reputed journals.



    Abstract
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    Abstract

    Estari Mamidala
    Kakatiya University, India

    Background: The search for new alternative and effective treatment methods were ongoing for obesity which is worldwide epidemic that reduces life expectancy. The present study aimed at investigating anti-obesity potential of physagulin-F isolated from Physalis angulata fruits. Methods: The rats were randomly divided into six groups i.e., (1) Normal Diet (2) Normal Diet with 50 mg/kgBW of physagulin-F (ND + 50 mg/kgBW); (3) Normal Diet with100 mg/kgBW of physagulin-F (ND + 100 mg/kgBW); (4) High Fat Diet (HFD); (5) High Fat Diet and 50 mg/kgBW of physagulin-F (HFD + 50 mg/kgBW); (6) High Fat Diet and 100 mg/kgBW of physagulin-F (HFD + 100 mg/kgBW). Through analyses of changes in body weight, visceral fat weight and blood biochemicals like total cholesterol, triglycerdies, HDL-C, LDL-C, insulin, adipoectin, leptin and fecal fat content anti-obesity potential was evaluated. Results: Rats receiving physagulin-F together with HFD showed significant (p < 0.05) reduction in body weight gain compared to rats receiving HFD only. At the end of study, the body weight gain of physagulin-F treated rats was not significantly (p > 0.05) different with those of normal diet rats. plasma lipid profiles, insulin, leptin, and adiponectin like obesity biomarkers levels also showed significant improvement (p < 0.05). Administration of physagulin-F caused significant (p < 0.05) increase in fecal fat excretion, which validates the hypothesis of lipase inhibition, similar to standard drug of Orlistat. Conclusion: This study concludes that the physagulin-F isolated from P. angulata fruits showed anti-obesity properties by inhibition of intestinal lipid absorption and also by modulation of adipocytes markers.

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    Title: Fractalkinea as an inflammatory marker in obese subjects

    Mohsen Khalid
    Gulf Medical University, UAE

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    Biography

    Mohsen Khalid
    Gulf Medical University, UAE

    Mohsen Khalid has graduated from faculty of medicine Cairo University in November 1980. He has completed his Master degree in Internal Medicine May 1986, and then he completed his Medical Doctorate in Internal Medicine November 2003. He is a consultant of Diabetes and Endocrinology in the Egyptian National Institute of Diabetes and Endocrinology. He has published more than 20 papers in reputed journals. The research interest of Prof. Dr. Mohsen Khalid is Genetics of Diabetes, diabetic complications and how to assist diabetic patients to live a good life with life style modification and medical treatment.



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    Abstract

    Mohsen Khalid
    Gulf Medical University, UAE

    Background: Fractalkine (CX3CL1) is known to convey its signals through a single G protein coupled receptor (CX3CR1). It is characterized as a structurally unique chemokine with both membrane-bound and soluble forms. Fractalkine expression has been detected in activated or stressed endothelial, smooth muscle, skeletal muscle, macrophages, neurons, hepatocytes and adipocytes. Inflammation up regulates Fractalkine particularly in adipose tissue of obese individuals. Aim of Work: This study was designed to assess fractalkine level in obese subjects and its relation with some clinical and laboratory finding It compares basal plasma fractalkine and hs CRP in obese patients (with and without metabolic syndrome) and lean healthy controls. Subjects and Methods: The study was carried out on 140 subjects; 70 controls and 70 obese subjects 38 with metabolic syndrome and 32 without metabolic syndrome. All were subjected to full history taking, thorough clinical examination, fasting and post prandial blood glucose, HbA1c, lipid profile, fractalkine level and hs CRP. Results: Serum fractalkine level was significantly raised in obese subjects compared to lean controls (being higher in those with metabolic syndrome). There was a significant positive correlation between serum fractalkine level and BMI, WC, WHR, fasting and post prandial blood glucose, HBA1c, total cholesterol, triglycerides and LDL and it was inversely correlated with HDL while there was no significant correlation between serum fractalkine level and hs CRP. Conclusions: Fractalkine, like other known adipocyte derived chemokines was increased in obese individuals and associated mainly with metabolic syndrome. This is a step in the way to understand and explain the exact pathogenesis of metabolic syndrome as well as obesity linked complications.

    Time:

    Title: Effects of High Protein and Balanced Diets on Lipid Profiles and Inflammation Biomarkers in Obese and Overweight Women at Aerobic Clubs: A Randomized Clinical Trial.

    Reza Ghiasvand
    Isfahan University, Iran

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    Biography

    Reza Ghiasvand
    Isfahan University, Iran



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    Reza Ghiasvand
    Isfahan University, Iran

    BACKGROUND: We studied the effects of high protein (HP) and balanced diets (BDs) on lipid profiles, and high-sensitive C-reactive protein (hs-CRP) levels in obese and overweight women. METHODS: In a parallel designed randomized controlled clinical trial, 60 healthy women with body mass index ≥25 kg/m2, aged 20-46 years, enrolled in an 8-week investigation at aerobic clubs. They were categorized into two groups (HP and BDs), randomly. Fasting lipid profile and hs-CRP levels were evaluated at the beginning and end of the trial. We assessed dietary intake by 3-day records and also used SPSS (version 18; SPSS Inc., Chicago, IL, USA) for data analyzing. RESULTS: Fifty-six participants completed the intervention. Concentrations of low-density lipoprotein cholesterol (P< 0.001 in BD group vs. P =0.023 in HP group) and high-density lipoprotein cholesterol (P< 0.001 in BD group vs. P =0.002 in HP group) increased significantly in both groups. Circulating triglycerides levels increased in both intervention grows, but the change in the HP group was not significant compared with the other group (P = 0.007 in BD group vs. P =0.099 in HP group). Whereas total cholesterol concentration decreased but not significantly so (P = 0.53 in BD group vs. P =0.73 in HP group). There were marginally significant decreases in the hs-CRP levels due to both diets (P = 0.057 in BD group vs. P =0.086 in HP group); however, there were no significant differences between the groups. CONCLUSIONS: Administration of HP and BD in overweight and obese women with regular aerobic exercise showed improvement in lipid profiles and hs-CRP levels within the groups, but there were no significant differences between groups.

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    Mark Lemstra
    University of Saskatchewan, Canada

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    Biography

    Mark Lemstra
    University of Saskatchewan, Canada

    Mark Lemstra has completed eight university degrees: Bachelor of Science, a Master of Science in Physical Medicine and Rehabilitation, a PhD in Psychiatry, a Master of Science in Public Health, a Master of Science in Epidemiology, a Doctor of Science in Public Health, a Doctor of Science in Epidemiology and a PhD in Epidemiology.



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    Mark Lemstra
    University of Saskatchewan, Canada

    Background: According to Statistics Canada, the number of adults that are overweight or obese rises every year in Canada. As such, it is obvious that various public policies are not working. After extensive community consultation, the Healthy Weights Initiative (HWI) started in Moose Jaw and and expanded to Regina, Saskatchewan, Canada. Objectives: To determine adherence, factors impacting adherence, and impact on various health outcomes Methods: From January 2014 to March 2015, 229 participants started the comprehensive six month HWI program. It was determined that having a buddy and signing a social support contract with three additional family members or friends were important to program adherence. As such, both went from being recommended to becoming mandatory. From April 2015 to August 2016, 771 additional participants started the program allowing evaluation of the two new policies. As well, HWI participant adherence was compared to 100 YMCA new members. Results: Among the first 229 HWI participants, 79.9% completed the six-month program. After the two new policy changes among 771 participants, 96.1% completed the HWI program (RR = 1.20; 95% CI = 1.01-1.49). In comparison, among new YMCA regular members without supervision or assistance, 14.0% were still fully adhering to their fitness program after six months (RR = 6.85; 95% CI = 3.88 - 12.10). After logistic regression, the only variable with an independent effect for not completing the HWI program was not having a spouse/partner supporting the program (OR = 2.31; 95% CI = 1.13 3.67). Although weight loss reductions were obtained (mean 9.5 pounds), the more significant benefits observed were numerous benefits to various health outcomes. For example, the prevalence of depressed mood reduced from 44% to 16.4% (p = 0.000). Conclusions: With two new policy changes including a mandatory buddy and a signed social support contract, the HWI has become more successful at promoting program adherence. As well, numerous positive health outcomes have been obtained during this free, community based initiative.

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    Title: ClC-3 Enhances Visceral Adipocyte Hypertrophy and Adipose Tissue Inflammation linking Obesity-Induced Insulin Resistance

    Xiaomiao Zhao
    Sun Yat Sen University, China

    Biography
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    Biography

    Xiaomiao Zhao
    Sun Yat Sen University, China

    Xiaomiao Zhao, MD.,Ph.D., an associate professor and associate chief physician of reproductive endocrine and advisor of Ph.D candidate, the vice president of Youth Committee of the Chinese OB/GT Committee of International Health Care Exchange and Promotive society. She has completed her M.D. at the age of 24 years and Ph.D at 30 years from Sun Yat-Sen University in Guangzhou, China and postdoctoral studies from Cedars-Sinai medical center, USA. Her research interest is in the field of reproductive endocrinology, mainly in polycystic ovary syndrome, androgen excess, insulin resistance, IVF, poor responder for ovary stimulation. Until now, Dr. Zhao has grown up to be the outstanding person of the field of reproductive endocrinology and leads the PCOS study group to the innovative science research, and has great performance of the clinical practice in IVF center. She has published more than 53 papers, among which, over 24 papers in reputed English journals (e.g. Fertility and Sterility, Clinical Endocrinology, International of Caner, and International Journal of Cardiology, etc.) and serving as a reviewer of International Journal of Cancer, JCEM and endocrinology. She takes charge of 11 research grants as a PI in China.



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    Xiaomiao Zhao
    Sun Yat Sen University, China

    Background and objective: We have previously found that chloride channel/antiporter ClC-3 gene knockout alleviates lipid and glucose disorders in mice model with type 2 diabetes. The present study was designed to verify the role of ClC-3 in adipocyte hypertrophy and adipose tissue macrophage (ATM) inflammation during obesity. Methods: We measured the ClC-3 expression and fat cell size in omental fat tissues from Chinese women with body mass index (BMI) from 16.0 to 28.4 kg/m2. The adipocyte cell size, ATM-mediated inflammatory phenotype switch and TLR-4/NFκB inflammatory signaling pathway was examined in visceral adipose tissue from ClC-3-/- and wild-type mice fed with high-fat diet (HFD) using micro-CT, histological, cellular, and biochemical molecular approaches. Results: The expression of ClC-3 mRNA and protein upregulated in omental fat tissues of obese women and has a strong positive correlation with BMI and adipose cell size. In HFD-induced obese mice, ClC-3 protein significantly increased as early as 4 weeks after HFD initiation. ClC-3-/- mice exhibited a dramatic decrease in HFD-induced body weight gain; VAT accumulation, adipocyte size enlargement or increased percentage of large adipocytes in VAT, as well as an improvement of obesity-induced metabolic disorders. ClC-3 deficiency also reduced obesity-induced ATM recruitment and accumulation, M1-like macrophage polarization and expression of pro-inflammatory cytokines through the TLR-4/NF-κB signaling pathway. In THP-1 differentiated cells in vitro, ClC-3 knockdown dramatically reduced LPS-induced NF-κB activation and TLR-4 expression, while overexpression of ClC-3 did the opposite. Conclusion: The upregulation of ClC-3 gene may contribute to obesity-induced adipose tissue dysfunction by promoting adipocyte hypertrophy and ATM inflammation, suggesting a therapeutic potential of inhibiting ClC-3 for obesity-related metabolic disorders

  • Sessions:
    Dietary Supplement, Nutrition & Healthy Lifestyle & Obesity Prevention and Control & Ties between Obesity and Diabetes

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    Title: Insulin Resistance Linking modulation of the Gut Microbiome to Dietary Recommendations and Health Claims

    Stoffer Loman
    NutriClaim, Netherlands

    Biography
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    Biography

    Stoffer Loman
    NutriClaim, Netherlands

    Stoffer has acquired a BSc-degree in Tropical Agriculture at the Royal Dutch College for Tropical Agriculture (Deventer, the Netherlands, was trained a Nutritionist (MSc) at WInsulin Resistance - Linking modulation of the Gut Microbiome to Dietary ageningen University (1992) and has obtained his PhD in Medical Sciences/Immunology at the Academic Medical Centre of the University of Amsterdam/ (1998). Following a career in the food supplement industry as science communicator and health educator he founded NutriClaim in 2007 (www.nutriclaim.com), providing specialist services pertaining to the scientific substantiation of health claims made on food, and in the marketing authorization of Novel Foods in the EU. Currently, Stoffer is also Work Package Leader in the EU FP7-funded project My New Gut



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    Abstract

    Stoffer Loman
    NutriClaim, Netherlands

    Obesity is one of the greatest public health challenges of the 21st century. Its prevalence has tripled in many countries of the World Health Organization (WHO) European Region since the 1980s, and the numbers of those affected continue to rise at an alarming rate. In addition to causing various physical disabilities and psychological problems, excess weight drastically increases a persons risk of developing a number of non communicable diseases), including cardiovascular disease, cancer and diabetes. Worldwide, current dietary recommendations dont refer to the role of the gut microbiome in health. Nevertheless, from a public health perspective, establishment of a physiologically relevant, beneficial health effect following modification of the microbiome on obesity should best be established by the favourable modification of one common denominator that is directly linked to a physiological beneficial effect. As common denominator of studies into the dietary modulation of the microbiome by probiotic and prebiotic foods, insulin resistance has been proposed. Not only is insulin resistance a hallmark in the development of obesity and type 2 diabetes, but it is also implicated in a plethora of disease states and diseases associated with metabolic syndrome, like excessive weight, hypertension, atherogenic dyslipidemia and chronic low-grade inflammation. This notion implies that insulin resistance should be one of the important, if not the most important primary outcome measure in clinical studies, applying pre- and probiotic interventions and performed in the context of applied microbiome research. Taken together, in order to make the shift from microbiome research towards its application in dietary strategies and recommendations, as well as into health claims made on newly developed microbiome modifying foods, we hypothesize that microbiome research should, at least in part, be targeted at deciphering the impact of (un)favourable modulation of the microbiome on insulin resistance.

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    Title: Comparison of Anxiolytic Effects of the Homeopathic Complex Vita-C 15 with Aconitum Napellus versus Diazepam in the Acutely Stressed C57BL6 Mice

    Charis Liew
    Cyberjaya University, China

    Biography
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    Biography

    Charis Liew
    Cyberjaya University, China

    Charis Liew Siaw Min has her expertise in the research on anxiety, depression and stress under the treatment and management of Traditional and Complementary Medicine (Homeopathy) and evaluation and passion in improving the mental health and wellbeing. She is currently doing on postgraduate study of Master in Medical Science (Msc) on the comparison of homeopathic and conventional intervention on anxiety and stress



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    Charis Liew
    Cyberjaya University, China

    Introduction: Anxiety, phobias and stress are the main mental health problems among the Malaysian population, with global prevalence varying from 8% to 18%. Even so, less than 30% who suffer these disturbances seek treatment. The objective of this study is to evaluate and compare the anxiolytic effects of Aconitum napellus and Homeopathic complex Vita-C 15 in the acutely stressed C57BL6 mice by using the fecal and serum corticoid test, and open field test (OFT). Methodology: A double blinded randomized controlled study was conducted at SPF animal facility of Brain Research Institute Monash Sunway (BRIMS)Jeffrey Cheah School of Medicine and Health Sciences of Sunway University Malaysia. All the animals were acclimatized to constant laboratory conditions for 14 days before starting the experiments. The treatments were carried out over 7 days. 48 male C57BL6 mice (n=6), 4-5 weeks of age were used. They were randomly selected and divided into two groups. Group I was the healthy control group of mice which were not exposed to acute stress. Group II (stress group); comprise of mice expose to acute restraint stress. Prior to restraint stress, the treatments given were Aconitum napellus 30 cH, Homeopathic complex Vita-C 15, Diazepam, and placebo. Then the results were evaluated by fecal and serum CORT test and open field test by comparing the anxiolytics effects between pre-test and post-test. Results The results showed higher levels of serum CORT and a significant increase in FCM than CON animals in acutely stressed animals on Day 7 (p<0.05). Acutely stressed animals demonstrated treated mice spent more time in the center had more entries into the center of the open field (p<0.001) and more active as measured in distance traveled in the center and traveled greater distance overall (p<0.001). Thus research into prevention and supportive therapies is necessary and beneficial for this disorder.

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    Title: Meet Moringa: A Superfood for Metabolic Resilience

    Carrie Waterman
    UCDAVIS University, USA

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    Biography

    Carrie Waterman
    UCDAVIS University, USA

    Dr. Carrie Waterman is an interdisciplinary research scientist at the intersection of nutrition, agriculture, health and development. She received her PhD in Pharmacognosy and spent the following years as a post doc in Natural Products Chemistry. She was a Fulbright Scholar at the University of Nairobi, Kenya and served as a Peace Corps volunteer in West Africa. She is currently a Professional Research Assistant in Nutrition at UC Davis with a NIH Fogarty International K01 grant. She is working with in Kenya on moringa, a plant used to treat malnutrition and prevent chronic diseases including diabetes and obesity.



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    Carrie Waterman
    UCDAVIS University, USA

    Moringa (Moringa oleifera Lam.) is an edible plant used as superfood and medicine throughout the tropics. A moringa concentrate (MC) was made by extracting fresh leaves with water utilized naturally occurring myrosinase to convert the glucosinolatesintochemically stable moringa isothiocyanates (MICS). MC and MICs significantly decreased inflammatory makers and glucose production in vitro. MC, supplemented in the diet at 5%, significantly reduced pathologies of metabolic syndrome in diet-induced obese C57 mice; MC-fed mice exhibited reduced weight gain and lower levels of insulin, leptin, inflammatory markers, liver damage, and cholesterol. Our results suggest a potential for stable and concentrated moringa isothiocyanates, delivered in MC as a nutritious food-grade product, to alleviate low-grade inflammation associated with chronic diseases and malnutrition. Future studies will evaluate the nutrient and MIC content of moringa varieties present in Kenya and mechanistic studies to understand the role of MC and MIC in diabetes and obesity prevention.

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    Title: Role of nutrition and nutraceuticals in preventing obesity

    TP Rao
    Taiyo Kagaku Co Ltd, Japan

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    Biography

    TP Rao
    Taiyo Kagaku Co Ltd, Japan

    Dr T.P.Rao has completed his PhD and postdoctoral studies at Nagoya University, Japan and a certificate course in International Food Laws and Regulations at Michigan State University, USA. He is General Manager at Taiyo Kagaku, Japan. He started his career at ICRSAT (International Crop Research Institute for Semi-Arid Tropics, India) and acquired extensive research, marketing and regulatory experience ranging in the fields of agriculture, nutrition to health. He has published one book and more than 65 papers in reputed journals and books. He has been serving as an editorial board member of NutraCos magazine and Austin Journal of Nutrition and Metabolism



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    TP Rao
    Taiyo Kagaku Co Ltd, Japan

    The prevalence of obesity may differ with age, ethnic background and economic conditions. However, the health implications associated with obesity were nevertheless same. Although the genetic factor may cause the obesity, the behavioral influence such as diet, physical activity and environmental factors have stronger influence on the prevalence and propagation of obesity. Therefore the energy balance in the intake and use of calories by the body plays a critical role in weight gain. Several healthy diet guidelines recommends eating veggie and low fat diets but excess intake of the same may again cause energy imbalance and therefore is less effective in preventing the weight gain. On the other hand nutraceuticals such as green tea, Garcinia combogia, Coleus forskohilli, fucoxanthinetc and supplements like Acetyl l-carnitine, 5-HTP and CLA etc are exhibited to be effective in fat burning and weight loss in adult populations. Maintenance of regular energy balance is the strategical and logical approach such as limiting the calories from the daily diet and increasing the pysical activity must be observed as routine and with the aid of nutraceuticals may effectively prevent the prevalence of obesity in both children and adults. Nutraceuticals targeting weight control alone does not support overall improvement, but rather a comprehensive approach tackling glucose metabolism, fat burning and circulation may require to counter obesity and related complications. A number of nutraceuticals are recommended for weight management while providing a proper nutritionalbalance.

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    Title: Supporting Health And Promoting Exercise (SHAPE) Programme for Young People with Psychosis

    Jo Smith
    University of Worcester, UK

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    Biography

    Jo Smith
    University of Worcester, UK

    Professor Jo Smith is a Professor in Early Intervention in Psychosis (EIP) at University of Worcester, Worcester, UK. Jo is a member of the International First Episode Physical Health Group (iphYs) promoting the physical health needs of young people with Psychosis in relation to their increased cardiovascular and diabetes risk. Jo is Project Lead of a physical health monitoring and intervention programme for young people with early psychosis called SHAPE funded through a Health Foundation (UK) SHINE Award 2014. SHAPE has been a finalist for several national awards including a National Institute for Clinical Excellence (NICE 2017) Shared Learning Award.



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    Jo Smith
    University of Worcester, UK

    Physical health problems are common in young people with psychosis who experience poor health and a significant reduction in life expectancy. mainly due to premature cardiovascular disease (CVD), underpinned by metabolic disorders like diabetes, and tobacco smoking. Moreover, the mortality gap compared to non-psychotic peers is widening. NICE (2014) developed 8 quality standards for the care of adults with psychosis and schizophrenia which included 2 physical health standards requiring services to complete a comprehensive physical health assessment and offer combined healthy eating and exercise programmes as well as help to stop smoking. This presentation will describe one of the first UK real world service evaluations of a bespoke EI physical health monitoring and intervention programme for young people with early psychosis called SHAPE. SHAPE offers a coordinated, multi-professional, 12 week well being and exercise programme in a youth focused, socially inclusive setting. Anthropometric data are measured at baseline, 12 weeks and 12 months post intervention. Mean baseline data revealed participants were at an increased health risk with elevated values in mean BMI (70% overweight/obese), waist circumference, resting heart rate, and triglycerides. Over 50% reported smoking daily and 52% of participants were prescribed highly obesogenic antipsychotic medications (Clozapine, Olanzepine). At 12 weeks and 12 months, no changes were observed in mean BMI, waist circumference or any other clinical variable (p > 0.05). Positive impacts on lifestyle behaviours included 7 participants eating ~400g of fruit/vegetables daily, 2 ceased substance use, 2 ceased alcohol use, 4 ceased smoking and 5 were less sedentary. SHAPE supported participants to attenuate their physical health risk following a 12-week intervention which was sustained at 12 months follow up. Participants also made positive lifestyle behaviour changes contributing to weight maintenance and physical health.

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    Title: Contextual influences affecting patterns of overweight and obesity among university students: a 50 universities population-based study in China

    Yang Tingzhong
    Zhejiang University, China

    Biography
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    Biography

    Yang Tingzhong
    Zhejiang University, China

    Tingzhong Yang, MD, Prof and Director of Social Medicine at Zhejiang University, China, where he is also a professor. He was appraised as an outstanding contributing scientist by the government of Jiangsu province in 1994. He was a advisor for the World Health Organization in delivering policy and program on tobacco control to health professions students, and served as an expert in updating management of CRDs in the WHO Global Action Plan 2013-2020. Dr. Yang is also a member of the expert group of National Association on Tobacco Control, and an external faculty affiliate of Injury Control Research, West Virginal University, U.S. His primary academic focus is health behavior, and research interests are in tobacco control, mental stress, and obesity .The Series of projects of tobacco control advocacy capacity covered all provinces in China, including more than 70 cities. In recent years he published more than 40 international papers. Several papers were cited by WHO report on the global tobacco epidemic, and other official documents. Core information of Global Health Professions Student Survey (GHPSS) in Tobacco Control in China was released by the United Nations.



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    Yang Tingzhong
    Zhejiang University, China

    Background: Many studies have examined childhood and adolescent obesity, but few have examined young adults and the effect of their home and current living environments on prevalence rates. The present study explores contextual factors affecting overweight and obesity among university students in China and, in particular, focuses on how the SES obesity relationship varies across different geographical contexts. Methods: Participants were 11,673 students, who were identified through a multistage survey sampling process conducted in 50 universities. Individual data was obtained through a self administered questionnaire, and contextual variables were retrieved from a national database. Multilevel logistic regression models were used to examine urban and regional variations in overweight and obesity. Results: Overall the prevalence of overweight and obesity in the study sample was 9.5% (95% CI: 7.7%, 11.3%). After controlling for individual factors, both attributes of the home location (regional GDP< Gross Domestic Product> per capita and rurality) and the current university location (city population) were found to be important, thus suggesting that the different origins of students affect current levels of obesity. At the individual level, while students with more financial resources were more likely to be obese, the extent of this relationship was highly dependent upon area income and city size. Conclusions:The results of this study add important insights about the role of contextual factors affecting overweight and obesity among young adults and indicate a need to take into account both past as well as present environmental influences when considering the role of contextual factors in models of the nutrition transition.

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    Title: Gender patterns of environmental variants in overweight and obesity among university students

    Shuhan Jiang
    Zhe Jiang University, China

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    Biography

    Shuhan Jiang
    Zhe Jiang University, China

    Shuhan Jiang, a PhD candidate, major in public health at Center for Tobacco Control Research, Zhejiang University, School of Medicine. Her primary academic focus is health behavior, and research interest is geographic health. Ms. Jiang recently conducted research as main member of four national projects, and published 15 papers. She won National Award for Distinguished Doctoral Candidate and 3rd Provincial Level Science Progress Award in 2016.



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    Shuhan Jiang
    Zhe Jiang University, China

    OBJECTIVES: The present study examines gender differences of individual and regional variants in overweight and obesity between men and women. METHODS: Participants were 11,942 college students identified through a multistage survey sampling process conducted in 50 universities in China. The data collection instrument was a self-administered questionnaire. Multilevel logistic regression models were used to examine individual and regional influences on overweight and obesity. RESULTS: The prevalence of overweight and obesity was 9.5% (95% CI: 7.7%, 11.3%) in the overall study sample, was double higher in males (13.9% <95% CI: 11.5%, 16.7%>) in males and (6.1% <95% CI: 4.1%, 8.1%>) in females, respectively. The final multiple level logistic model showed that higher family income and original GDP, higher perceived life stress and regional unemployment were associated with higher overweight and obesity in males. However, unlike male students, only regional unemployment was associated with overweight and obesity in the opposite direction among females. CONCLUSION: Our research underscores males were more sensitive to overweight and obesity, which were influenced by more environmental variants in males than in females. This information should be considered in formulating policy and designing and implementing effective interventions in overweight and obesity among male young adults.

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    Title: Obesity and Type-2 Diabetes

    Samuel Tilahun
    Jimma University, Ethiopia

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    Biography

    Samuel Tilahun
    Jimma University, Ethiopia

    Samuel Tilahun has his expertise in the area of animal production. The author studied his BSc and MSc at the then Alemaya and now Haramaya University, respectively, Haramaya, Ethiopia and Post Graduate Diploma in Agricultural Science at Lincoln University, Christchurch, New Zealand. Currently, the author engaged in offering different courses to undergraduate and post graduate animal science students and conducting research in the area of animal nutrition in Jimma University.



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    Samuel Tilahun
    Jimma University, Ethiopia

    Obesity is formally defined as a significant increase in ideal weight, ideal weight being defined as the level at which life expectancy is maximized. A key element of animal and human obesity is the hormone leptin which acts on nerve cells in the brain to regulate feed intake and body weight. Obesity is a major risk factor for the development of type-2 diabetes and is an important obstacle to the management of this disease. It is a leading cause of human morbidity and mortality. The other hormone that plays a role in energy homeostasis of mammals is ghrelin. In addition to hormonal effect, the prevalence of obesity in mammals has been linked to insufficient maternal nutrition during gestation. This paper also explores the pathogenesis of obesity and other metabolic disorders in relation with the hormone leptin and ghrelin. In addition, the impact of maternal nutrition during pregnancy to the development of obesity and type-2 diabetes and the possible options to modulate obesity and type-2 diabetes have also been assessed.

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    Title: The effects of a Combined Exercise Programme Aerobic and Resistance or Resistance Alone or Aerobic Alone on Blood Glucose, Incretin, Metabolic and Inflammatory Mediator that could Control the Diabetes and Increase Insulin Sensitivity in Type 2 Diabetes

    Nawal alsubaie
    De Montfort University, UK

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    Biography

    Nawal alsubaie
    De Montfort University, UK

    Nawal Hamad completed her MSC. Degree (Clinical Pharmacy International Practice and Policy) and currently she works as a Clinical Pharmacist, Prince Sultan Military Medical City, (PSMMC).



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    Nawal alsubaie
    De Montfort University, UK

    An excessive number of calories consumed daily, in addition to a sedentary lifestyle, are the main causes of increasing type 2 diabetes (T2D) prevalence worldwide (LEE, H.K. et al., 2010). Diabetes usually accompanied by hypertension, lipid disorders and obesity. Recent studies show that the reduction in HbA1c cause 35% relative risk reduction for fatal/nonfatal cardiovascular disease. Also 56% reduction in CVD when this reduction of HbA1c accompanied with systolic blood pressure (SBP) decrease. Moreover, 75% reduction in CVD if reduction of HbA1c and SBP accompanied with decrease in non-HDL level (Eeg-Olofsson et al., 2016). The aim of this study to prove that combination exercise is better than aerobic or resistance alone. It is going to compare T2D and ND who are doing combination exercise with same study groups who are doing either aerobic or resistance training. Moreover, it is going to compare the intervention group with control group of both T2D and ND who are following sedentary life style. All these comparisons to show if the changes in primary and secondary outcome are significant between the different groups. This study is also looking for the changes in incretin level in all groups to see if there is any effect of exercise on the secretion of this hormone and compare it to T2D who are using different medication for diabetes. T2D is considered as a serious disease, which needs immediate intervention. This intervention depends on the severity of the case. It could be either diet and exercise or pharmacological intervention by using anti-diabetic medication or insulin to control blood glucose levels within normal levels. It is necessary to check routinely to discover T2D at an early stage because identification and early treatment can prevent further complications in pre-diabetes or metabolic disorder. Diet and exercise can potentially prevent the development of T2D of many of those at risk or in early stages (Diabetes UK, 2016). Research questions 1- Are there demonstrable health differences after the six weeks exercise intervention? 2- Does exercise change glucose and lipid derangements? 3- Does exercise affect the inflammatory nature of T2D? 4- Are the metabolic and inflammatory profiles related? 5- Do the improvements correlate with medication type? 6- Do the improvement affect incretin involvement? Conclusion In T2D and ND combination exercise has significant effect on HbA1c, and the anthropometric variables (weight, waist, BMI and lung capacity). Previous studies and researchers had evaluated the effects that aerobic training and resistance training had on the glycaemic control in term of HbA1c in patients suffering from T2D (Sigal et al., 2007); (Yavari et al., 2012). This study shows reduction in BG after aerobic exercise more than after resistance, which illustrate that, performing resistance exercise before aerobic exercise improved glycaemic control during exercise (Yardley et al., 2013). OGTT shows a very significant improvement of BG level in both groups, that was higher in T2D. This suggests that combination exercise is valuable in improving insulin sensitivity in T2D. It was concluded that the combination exercise was the best exercise for improvements to insulin resistance (Davidson et al., 2009).

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    Title: Physical inactivity, Body composition and Obesity risk among young adults

    Cristiana Pop
    Bucharest Economic Studies University, Romania

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    Biography

    Cristiana Pop
    Bucharest Economic Studies University, Romania

    Dr. Cristiana Lucretia Pop is Professor at the Bucharest Economic Studies University, Physical Education and Health Department. Her research interests include: overweight and obesity risk assessment, well-being, quality of life, and promoting physical activity and a healthy lifestyle. She is member of Romanian Agency for Quality Assurance in Higher Education, member of Romanian Athletic Federation women commission and has research collaboration with Romanian Academy, Anthropological Institute Research Center. She is Senior Editor and Editorial Board Member of several reviews in education, health and sport sciences domain



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    Abstract

    Cristiana Pop
    Bucharest Economic Studies University, Romania

    Obesity and physical inactivity seem to have a common evolution and a reciprocal determination with disastrous combined effects on morbidity and mortality. Beside an average increase of weight and the predisposition to overweight and obesity, a decrease in fitness level and skills is observed in the newest generations. The excessive energy intake combined with the decreasing energy expenditure contribute to a concerning balance between fat and lean body mass even in young people. The weight management quantitative issues tackled in this research are weight, body mass index and body composition. The main research question is if the ratio between body fat and muscle mass could return different results regarding overweight and obesity risk, comparing with BMI results While by calculating BMI the estimated number of overweight and obese subjects was of 14 %, by measuring body fat percentage that number increased to 43% of the young women (19-24 years) in the research sample. The t test returns a significant difference between BMI values and the body fat percentage for the study sample: t (155) = 2.37 p<0,01. The conclusion is that BMI results may be insufficient for a correct estimation of overweight and obesity risk. The body composition adds useful information about health and fitness status. Considering that muscle mass is decreasing with age, promoting physical activities in preschools, schools, universities and among adults through active transportation, spending time or exercising outdoors as leisure time, or joining sport competitions in a proper environment could prevent sarcopenic obesity. Integrating physical and health education in overweight preventative strategies would have effect in reducing the occurrence of physical and emotional disorders and co-morbidities over the lifetime.

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    Title: Serum C1q/TNF-related protein-3 (CTRP3) levels may be a potential future biomarker in obesitp

    Neha Bindlish Jain
    University College of Medical Sciences & Guru Teg Bahadur Hospital, India

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    Biography

    Neha Bindlish Jain
    University College of Medical Sciences & Guru Teg Bahadur Hospital, India

    Dr. Neha Bindlish Jain was born in New Delhi, India, in 1984. After graduating from University College of Medical Sciences and Guru Teg Bahadur hospital, Delhi, in the year 2008, she is currently pursuing her MD Physiology from the same institution. She also underwent a short term training course in autonomic function tests from Department of Physiology, AIIMS, Delhi, for a better understanding of her current research interest. To the best of her knowledge, the current research on C1q/TNF Related Protein 3 (CTRP3) and obesity shall be the first one to be conducted in India. This current research is her gateway to pioneer in the field of Physiology



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    Neha Bindlish Jain
    University College of Medical Sciences & Guru Teg Bahadur Hospital, India

    Background- We hypothesized that higher circulating levels of a novel adipokine CTRP3, would promote a favorable metabolic profile in obesity. Objective- To study and correlate the circulating levels of serum CTRP3 and metabolic parameters in obesity. Design- A non- randomized case control study in a tertiary care hospital. Subjects & Methods- Sixty subjects were recruited from general population into the study and control groups, based on Body mass index (BMI as kg/m2). There were no drop outs. Newly diagnosed, drug naÔve obese subjects with BMI 25-35kg/m2 of both genders, aged 18-40yrs, with no associated co-morbidity or substance abuse, were grouped as CASES (n=30) and compared with age, sex and socioeconomic status matched CONTROLS (n=30) with BMI 19- 22kg/m2. The baseline fasting metabolic parameters (HbA1c, SBP, DBP and TSH) were within normal range in both the groups, thus excluding confounders for CTRP3 and obesity. Statistical analysis- Unpaired Studentís t-test and Pearsonís correlations and linear regression using SPSS-20 software. Data was presented as mean Ī SD. p <0.05 was considered significant. Results- We found lower levels of serum CTRP3(p<0.001), adiponectin(p=0.025), HDL(p<0.001), and higher BMI(p<0.001), leptin(p=0.04), insulin(p=0.003), HOMA-IR(p<0.001), LDL(p<0.05) and atherogenic index(p<0.001) in cases. Also, CTRP3 inversely correlated with serum triglycerides(p<0.001), atherogenic index(p=0.04), leptin(p=0.02), and positively with adiponectin(p=0.02) in obese group. Conclusions- Serum CTRP3 levels are lowered in obesity. This was probably the first study to show that CTRP3 levels are inversely correlated with the atherogenic index in obesity. Hence, in future, optimizing CTRP3 levels may prove as a potential therapeutic target to improve obesity and its co-morbidities. Key Words- C1q/TNF-Related Protein-3 (CTRP3), Body Mass Index (BMI), Obesity, Adiponectin, Leptin & Atherogenic Index.

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    Title: Paraoxonase activity in obese patients following exercise-based cardiac rehabilitation program

    Ehud I. Goldhammer
    Cardiac Rehabilitation & Sport Medicine Center, Israel

    Biography
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    Biography

    Ehud I. Goldhammer
    Cardiac Rehabilitation & Sport Medicine Center, Israel



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    Abstract

    Ehud I. Goldhammer
    Cardiac Rehabilitation & Sport Medicine Center, Israel

    Purpose: The effect of weight on paraoxonase activity was determined in 39 ischemic heart disease patients, 14 of whom with BMI 30 who underwent a 12week aerobic exercise training program. Background: Paraoxonases have been found to perform a number of biological functions, though the primary role of this group of enzymes is still a topic of speculation. Some of the observed roles have revealed activities of anti-inflammatory, anti-oxidative, anti-atherogenic, anti-diabetic, anti-microbial and organophosphate-hydrolyzing properties Methods: Paraoxonase activity was measured by its arylesterase activity spectrophotometrically, at 250 degrees C, wavelength 270 nm. Results: A 15.9 increase in paraoxonase activity was found following the 12week exercise program. In addition, there was a significant BMI (body mass index) effect with higher mean paraoxonase levels among women during both pre-exercise 16.8 and post-exercise 19.5.2 training, p<0.05. Conclusions: Aerobic exercise training was found to be an effective means in inducing plasma levels elevation of the antioxidative, antiatherogenicparaoxonase in patients with coronary artery disease, and particularly in obese patients.

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    Title: The impact of a combined aerobic and resistance exercise programme in preventing or delay to the onset of diabetes for subjects at risk

    Bandar Manawer al Harbi
    De Montfort University, UK

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    Biography

    Bandar Manawer al Harbi
    De Montfort University, UK

    Bandar Manawer al Harbi completed his Master of Science With Merit Pharmaceutical Quality by Design. Currently he is working as a Assistant Director of Pharmacy for Material Management Prince Sultan Military Medical City.



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    Bandar Manawer al Harbi
    De Montfort University, UK

    Pre diabetes describes a condition whereby an individuals level of blood glucose is above normal level, though not high enough to warrant them a T2D diagnosis. The condition is classified into two categories, impaired glucose tolerance (IGT) where blood glucose levels are above the normal 2 hours after glucose loading in the oral glucose tolerance test but not so high to warrant the classification as diabetes. The other is impaired fasting glucose (IFG) where blood glucose have risen to a fasting state but yet again, not so high to warrant the classification as diabetes. Physical exercise improves BG homeostasis but the extent to which exercise is effective strategy as primary prevention mechanism for people whom at risk to develop diabetes is not fully understood. Purpose: To examine the effects of 6 weeks moderate intensity combined aerobic and resistance exercise program in preventing or delaying the onset of diabetes for subjects at risk compared to sedentary non diabetic individuals. Methods: 20 subjects of a sedentary lifestyle, diagnosed with either pre diabetes or at risk to developed T2D (PRE-D) and 5 Subjects were sedentary healthy individuals (ND) met the inclusion criteria. Both PRE-D and ND have been asked to complete 6 weeks of moderate intensity combined aerobic and resistance exercise for 60 minutes on two days or week. Each exercise session consists of a combined exercise protocol of 30 minutes of resistance exercise (3 sets of 10 repetitions) followed by 20 min cycling. The primary outcome is to concentrate on metabolic results, such as improved HbA1c, blood pressure, heart rate, 1 repition max, lipid profile (reduction in Total Cholesterol, Low Density Lipoproteins, Triglycerides or increase High Density Lipoproteins) and improvements in insulin sensitivity determined by responses to oral glucose tolerance tests on independent days. Results: There were significant reduction (p=0.00) on the HbA1c after applying of 6 weeks combination exercise intervention in both groups comparing to baseline. OGTT indicated significant differences between Pre Exercise & Post 12th exercise session in both groups with p=0.01. BG concentrations were reduced post each exercise session and was significant Post EX S12 comparing PRE EX to P= 0.00 and P=0.09 in PRE-D and ND respectively. A significant reduction in TC (P=0.04) and LDL (P=0.02) in PRE-D only. SBP drops from 127.3 13.1 to 119.6 8.4 mmHg with P=0.04 in PRE-D while in ND was not significant. HR was significantly reduced (P=0.01) and goes from 73.5 10.3 to 70.3 12.1 in PRE D and was significantly reduced (P=0.03). A significant reduction in RPE have been achieved with P=0.00 in PRE D and P=0.03 in ND group 1RM improved significant in back (P=0.04) and triceps (P=0.04) in PRE D, while in ND group the significant improvement was in squat (P=0.02) and back (P=0.02). Conclusion: A combination exercise programs, which involves both RE, and AE performed at moderate intensity (50 to 60% of 1RM) over 6 weeks period can be feasible and economical prevention strategies to minimize the risk factors for T2D in prediabetes subjects

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    Title: Severe Diabetic ketoacidosis in a Newly Diagnosed Child with Type 2 Diabetes Mellitus

    Mohammed AlAgha
    King Abdulaziz University, Saudi Arabia

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    Biography

    Mohammed AlAgha
    King Abdulaziz University, Saudi Arabia

    Mohammed AlAgha is a senior medical student at King Abdulaziz University, Jeddah, Saudi Arabia. Currently he is in the internship year and he is enjoying his last eleven months left for him before graduation. During his 6 years in medical school, he had an outstanding performance, and has maintained his positionat the top of the deans list for the top ten students. He has started his journey of research by two researches, and has previously presented one of them in a conference held in Jeddah, 2016



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    Mohammed AlAgha
    King Abdulaziz University, Saudi Arabia

    Background: Diabetic ketoacidosis (DKA) is an acute complication of both type 1 and type 2 diabetes mellitus (DM). DKA is characterized by the presence of hyperglycemia, ketosis, ketonuria, and metabolic acidosis. Cerebral edema is a rare but rather a serious complication of DKA. Case presentation: An obese 12-year-old, Egyptian boy, previously medically free, presented to the emergency room (ER) of King Abdulaziz university hospital, with two weeks' histories of dizziness, shortness of breath, polyuria, polydipsia &nocturia. His symptoms were deteriorating with a change in sensorial and cognitive functions at the time of presentation. He was diagnosed with type 2 DM based upon clinical background, namely the presence of obesity (weight+7.57 Standard Deviation Score (SDS), height+1.4 SDS, and body mass index (BMI) of 34.77 kg/m2 (+3.97SDS) together with the presence of Acanthosisnigricans and biochemically based on, normal level of serum insulin, normal serum level of connecting peptide and negative autoantibodies. He was presented with severe DKA, based on clinical and laboratory criteria. During the first 12 h of hospitalization, the patient has developed cerebral edema based upon clinical and radiological bases with the requirement of intensive therapeutically managements with final complete clinical, biochemical and radiological recovery. The patient was discharged home on oral metformin therapy after gradual weaning from insulin therapy, which was needed initially during his acute presentation. We aimed to present a rare presentation of severe DKA with cerebral edema in a child with Type 2 DM. Conclusion: Despite type 1 DM is the commonest type of diabetes in children, pediatricians should be aware of other types of diabetes, particularly type 2, as the prevalence of obesity in children is increasing. Children with type 2 DM are also prone to develop DKA, thus proper and rapid investigations to diagnose DKA in suspected patients are mandatory. Those patients are also at risk to develop cerebral edema, thus proper monitoring for neurological symptoms during the management of DKA is crucial.

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    Title: High Dietary Diversity is Associated with Child Obesity in Iranian School

    Sahar Hooshmand
    SNDT Womens University, India

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    Biography

    Sahar Hooshmand
    SNDT Womens University, India

    Dr. Sahar Hooshmand is an academician and researcher in the field of epidemiological childnutrition. She had a practice career graduating from S.N.D.T. Women's University of Mumbai, India.She published and presented several papers in some congress and journals. she has written three educational nutrition books.She is participated as lecturers at department of food science and nutrition in Iran and as trainer in Family education courses conducted by education and training organization. She is honored to get awards for child nutrition and dietary diversity papers by University of hohenheim, Germany (2012) and International nutrition foundation (INF), USA (2013).



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    Sahar Hooshmand
    SNDT Womens University, India

    Objective: The prevalence of overweight and obesity in Iranian children has increased considerably in the last decades. Obesity in children is a major concern. Higher variety score of die may cause obesity are overweight among urban schoolchildren. The objective of this study was to measure dietary diversity score and obesity in child from Iran. Methods: The present study examined Dietary Diversity Score(DDS) and weight status by calculating Body Mass Index (BMI) and the World Health Organizations (WHO) anthropometric indices of weight-for-age (WA) and weight-for-height. A cross-sectional study was performed on 2234 Iranian aged 6-9 years, attending primary schools residing in urban area from low and middle income categories. Dietary diversity scores were assessed based on frequency of consumption of individual food items categorized into 11 individual food groups. Results: Overweight children showed the highest mean score for cereals (F=2.209, P=0.005), vegetables (F=5.234, P=0.001), non-vegetarian foods(F=12.3920, P=0.000), mixed dishes (F=9.899, P=0.000), beverages(F=9.654, P=0.000), sweets and sugar(F=5.122, P=0.002) and fats(F=10.263, P=0.000). Mean scores for vegetables, sweets, beverages and fat consumption increased with increasing weight. High scores for pulses and legumes consumption was observed in obese children. Scores for vegetable consumption were higher among overweight children. Conclusion: Overweight and obese school children had high diversity scores in their diet.

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    Title: Assessing Antioxidant Micronutrients Status and Risk of Cardiovascular Diseases among Type 2 Diabetic Outpatients in Ghana

    Odeafo Asamoah
    Kwame Nkrumah University, Ghana

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    Biography

    Odeafo Asamoah
    Kwame Nkrumah University, Ghana

    OdeafoAsamoah-Boakye is a graduate research student in Nutrition and Dietetics at Kwame Nkrumah University of Science and Technology. He is also attended 4 international conferences in Ghana, and made one oral presentation. He is a young scientist who have to my credit 2 publications and 4 manuscripts under review. He is highly motivated research and has engaed in PhD research volunteer in my institution. His research areas has been diabetes, obesity and cardiovascular diseases.



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    Odeafo Asamoah
    Kwame Nkrumah University, Ghana

    Background:Dyslipidemia is a major risk factor of cardiovascular diseases, which in turn contribute 68% of mortality among type 2 diabetes. Conversely, intakes ofantioxidant micronutrients can delay or prevent diabetic complications such as cardiovascular diseases. The study aimed to assess antioxidant micronutrient status and risk of CVDs among Type 2 Diabetic Outpatients. Methods: A cross sectional study was conducted on type 2 diabetics. . Dietary intakes of antioxidant micronutrients were assessed using 24-hour dietary recall. Anthropometrics including Body Mass Index, waist circumference, and biochemical indices, includingglycatedhaemoglobin (HbA1c), fasting blood glucose (FBG), coronary risk, atherosclerosis risk, serum zinc and lipids profile were measured in 152 participants. Data were analyzed using SPSS version 23. Results:Thirty-seven (24.3%) were males and 115 (75.7%) were females. Also, 74.3% of type 2 diabetes patients had high FBG and 64.6% had high HbA1c. The prevalence of single dyslipidemia, combined dyslipidemia and mixed dyslipidemia were 63.8%, 15.8%, and 1.3% respectively. Also, 35.3% of subjects had high coronary risk and 5.3% had high atherosclerosis risk. The mean intakes of zinc (5.04 2.76 mg/day), vitamin E (5.16 2.60 mg/day) and vitamin C (82.72 38.76 mg/day) were lowered among type 2 diabetes patients. When controlling for age and gender, inadequate vitamin E was directly associated with HbA1c, (r=0.220, p=0.033), Total Cholesterol (TC), (r= 0.260, p=0.011), Low density lipoprotein Cholesterol (LDL-C) (r= 0.267, 0.009) and coronary disease risk (r=0.217,p=0.036). Coronary risk was strongly associated with TC (r=0.690, p< 0.0001) and LDL-C, (r=0.783, p< 0.0001), while atherosclerotic risk correlated with serum Triglycerides (TG), (r=0.817, p< 0.0001) and VLDL-C, (r=0.817, p< 0.0001). Serum zinc was reduced among participants and had inverse relationship with glycated haemoglobin (r= -0.206, p=0.05) and fasting blood glucose (r = -0.227, p value = 0.033 Regression analyses revealed that a point increase in TC was associated with 2.6-folds increased odds of coronary disease risk (OR= 2.6, 95% CI=1.9-3.7, p< 0.0001), TG was associated with 2-folds higher coronary risk (OR= 2.5, 95% CI= 1.3-4.8, p=0.004), and LDL-C was associated with 5- folds higher coronary disease risk (OR= 4.9, 95% CI=2.9-8.1, p< 0.0001) among participants. Conclusion and Recommendation: Uncontrolled blood glucose and atherogenicdyslipidemia was common among these diabetics, were significantly associated with high coronary disease risk, and atherosclerotic risk. Management of diabetes in Ghana needs a critical look at to increase effectiveness and reduce the burden of the disease.

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    Title: Marine Microalgae improve Lipoproteins lipases white adipose tissue in pregnant and offspring of dietary obese rats dams

    Bendimerad Soraya
    University of Tlemcen, Algeria

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    Biography

    Bendimerad Soraya
    University of Tlemcen, Algeria



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    Bendimerad Soraya
    University of Tlemcen, Algeria

    Maternal obesity is associated with increased adiposity and alter depression of genes in the adipose tissue of the fetus, including increased expression of LPL[1]These findings, suggestive of the protective effects of marine food sources against heart disease, have prompted the study of mechanisms for the hypotriacylglyceridaemic action of w3 fatty acid [2].The aim of the present study was to determine the time course of changes LPL adipose tissue in cafeteria-diet-fed and cafeteria diet supplemented green microalgae dams during gestation, lactation and pups at weaning. The study focuses on four groups of pregnant rats and offspring consuming the control diet or cafeteria diet supplemented or not by marine unicellular algae, LPL white adipose tissue was measurement, tissue homogenates were prepared by homogenizing 100 mg of tissue for 1 min in 4 ml of 50 mM NH4Cl/aq. Our results shown that the cafeteria plan provide an obese phenotype with alterations mainly causing an increase in TG, VLDL-TG and LPL. The supplementation of 10% of marine microalgae reduced TG, VLDL-TG and higher LPL in obese pregnant rats-algae and offspring. In conclusion, maternal over nutrition has long term metabolic consequences. The supplementation of 10% marine microalgae can reduce this disorder by a significant increaseLCPUFAn-3. Key words. Adipose tissue,w3, LPL, obesity

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    Title: Ethno Pharmacological and Ethno medicinal Study of Plants Used in the Treatment of Obesity in Cameroon

    Nole Tsabang
    University of Yaounde, Cameroon

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    Biography

    Nole Tsabang
    University of Yaounde, Cameroon



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    Abstract

    Nole Tsabang
    University of Yaounde, Cameroon

    Abstract: Aim of study: Obesity is a leading preventable cause of death worldwide, with increasing rates in adults and children. Nowadays, the number of fat and obese people is increasing in Cameroon and many of them in all likelihood develop various diseases, particularly heart diseases, type 2 diabetes, certain types of cancer and osteoarthritis. Fat or obese people present an abnormal accumulation or excess body fat that may have a negative effect on health, leading to reduce life hope and/or increased health problems. This disorder is most commonly caused by a combination of excessive energetic food intake, lack of physical activity, and genetic susceptibility, although a few cases are caused primarily by genes, endocrine disorders, medication and/or psychiatric diseases. People are considered obese when their body mass index (BMI), a measurement obtained by dividing a subjects weight by the square of the person's height, exceeds 30 kg/m2, and fat when their BMI is equal or superior to 25. Methods: In the present study, we carried out an ethno pharmacological survey of anti-obesity plants in Cameroon. Recorded herbal medicines were detailed described and the standardization of dosages were investigated. We also did a systematic review about their safety and efficacy in the management of obesity in human by searching bibliographic data bases such as, Google Scholar, Pub Med, Scopus and Web of Science, for studies reported between April 2012 to February 2014 on human or animals, investigating the beneficial and harmful effects of herbal medicine to treat obesity in Cameroon. Results: A total of twenty anti-obesity plants were recorded. Flavonoids extracted from the fruits of Solanum melongena (Cheucheu in Bamileke tribe) at a dose of 1mg/100g BW/day showed significant hypolipidemic effect in normal and cholesterol fed rats. Studies reported on Irvingia gabonensis and I. wombolu (two species of West and Central Africa, African bush mangoes) showed significant decreases in body weight. African mangoes seeds seem to have satisfactory anti obesity effects. The effect magnitude of each of recorded medicinal plants is a critical point that should be considered for interpretation. While there was no report for side effect in these species, we believe that safety of these plants still remains to be elucidated by further literature researches or long-term studies for their better exploitations. Key words: Herbal medicine, Obesity, Cameroon, Systematic review, efficacy, safety

  • Sessions:
    Childhood obesity & Surgical and Non-Surgical Treatments

    Time:

    Title: Tackling Childhood Obesity and its Long Term Health Outcomes One Bite at a Time

    Theresa Loomis
    State University of New York, USA

    Biography
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    Biography

    Theresa Loomis
    State University of New York, USA

    Dr. Loomis received her B.S from the University of Rhode Island and her M.S. and Doctorate of Clinical Nutrition from the University of Medicine and Dentistry of New Jersey. She is a Registered Dietitian (RD) with 16 years of experience in pediatric nutrition. Dr. Loomis has conducted presentations on a local and national level on a number of areas including the impact of Registered Dietitians in the Neonatal Intensive Care Unit (NICU), Combating Childhood obesity and Pediatric Food Allergies and Treating Picky Eating. Her doctoral work looked at the impact of standardized feeding guidelines for low birth weight infants, which was recently published in the Journal of Pediatric Gastroenterology and Nutrition. Dr. Loomis current research looks at the impact of nutrition counseling on childhood obesity, and the eating habits of picky eaters as well as the impact of role modeling on the eating habits and weight status of college students. Dr. Loomis is an Assistant Professor at SUNY Oneonta and is the Director of the Masters Program and Dietetics Internship. She also works as a pediatric dietitian in a pediatricians office counseling children who struggle with obesity and has owned her own private practice since 2010.



    Abstract
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    Abstract

    Theresa Loomis
    State University of New York, USA

    Childhood obesity is a growing concern worldwide. It has becoming a problem in every country where there is data. Children who are born preterm or Small for Gestational Age (SGA) are at higher risk for developing childhood obesity than their peers who are born on time and of normal weight. This presentation will discuss the impact that the development of obesity has not only on the more commonly known long term health consequences such as diabetes, hypertension and cardiovascular disease, but it will also discuss its impact on the development of food allergies and other inflammatory diseases. The eating habits during the perinatal period and breastfeeding and their impact on the development of obesity will also be described. We will explore the impactindividual nutrition counseling has on childhood obesity compared to group counseling and virtual counseling. Finally evidenced based strategies to prevent the onset of obesity during pregnancy, breastfeeding and childhood will be presented.

    Time:

    Title: The cutoff points in the metabolic syndrome during childhood and trends changing with sexual maturation stages

    Oya Yucel
    Baskent University, Turkey

    Biography
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    Biography

    Oya Yucel
    Baskent University, Turkey

    Oya Yucel obtained his medical degree as MD in 1985 at the Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey. She was trained at the Haydarpasa Numune Educate and Research Hospital. She worked at the Sakarya University and was Erasmus coordinater and later at the Baskent University, Istanbul Hospital, Pediatric Department, until now. She was the head of research projects at seven studies. She is "Editorial board member"of World Journal of Gastroenterology and Journal of Pediatric Intensive Care. She is a member of several scientific national and international societies (Turkish Pediatric Society, Turkish National Pediatric Society, European Academy of Pediatrics).



    Abstract
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    Abstract

    Oya Yucel
    Baskent University, Turkey

    The prevalence of obesity and its metabolic complications in pediatric populations is increasing in worldwide. The main problem was to decide which parameters take into account for scoring system in children to evaluate these risks in future. There is no concensus for the diagnosis of metabolic syndrome (MetS) in childhood. In the current study, Receiver operating characteristic (ROC) curve analysis was carried out to identify the best cut off points of parameters (WaC, TChol, TG, HDL, LDL, fasting glucose and insulin, HOMA-IR, SBP, DBP, MAP.). The highest value for Youden's index was accepted as the best cutoff value (J =max[SN+SP]). The sensitivity and specificity of the cutoff values were also presented. Five parameters including highest value of AUC were choosen as an individual MetS criteria. The presence of at least three of the five criteria was defined as the presence of MetS. The main criteria of MetS were determined as elevated WaC, TG, SBP, HOMA-IR and low HDL. There are no statistical differences between gender, except for elevated SBP (p: 0.028) and WaC (p: 0.005) which higher in boys. The rate of obesity was 46.4% and most of them were in pre-pubertal stage (59.4%). Out of 116 children with MetS, 75.9% was obese. The rates of MetS were increasing in pre/mid-pubertal stages among boys and in post-pubertal stage among girls (32.1 %, 13.2%, 54.7% in girls and 49.2%, 34.9, 15.9 in boys, respectively p<0.001). The rate of MetS in children with obesity was 82.2% (48% in pre-, 17% in mid- and 35% in post-pubertal stages) and it was 35.4% among non-obese children. In children with obesity, the most common abnormalities were elevated WaC (89%), elevated HOMA-IR (77%), low HDL(68%), TG (50%), SBP (16%). WaC was correlated with insulin and HOMA-IR. The prevalence of IR was also increasing parallel to increase obesity ratio and IR was observed in almost two third of children with obesity. In conclusion, WaC measurement is the easiest way to recognize metabolic disorders even in younger children because of elevated WaC predicts IR and obesity.

    Time:

    Title: Prevalence of hyperinsulinism, type 2 diabetes mellitus and metabolic syndrome among Saudi overweight and obese pediatric patients

    Abdulmoein Eid Al-Agh
    King Abdul Aziz University, Saudi Arabia

    Biography
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    Biography

    Abdulmoein Eid Al-Agh
    King Abdul Aziz University, Saudi Arabia

    Abdulmoein Al Agha is a Professor of Pediatrics & Pediatric Endocrinology at King Abdul Aziz University. He received his Fellowship certificate in Pediatric Endocrinology and Diabetes from Sydney, Australia, 2001. Fellowship of the Royal College of Physician (Edinburg) since 1997, and graduated King Abdul Aziz University Medical School, Jeddah, Saudi Arabia, 1991. He has many present and past academic and administrative positions including; MRCPCH Overseas examiner and host as well supervisor for Saudi Board Pediatric residency training for western Region since 2001. He is a coordinator, Pediatric Club Western Region, since 2007 to present. He is the chairman of Reproductive Modules "New Faculty Curriculum" from 2009 to present. He was acting Chairman, of Pediatric, KAUH 2006-2007. He is as well, a visiting instructor and teacher, Ibn- Sina Medical School, 2008 to present. He has been invited to be an external examiner for many of Gulf and Arab countries; including Bahrain, Kuwait, United Arab Emirates, Oman, and Egypt for Pediatric under and post graduates as well for Endocrine examinations. He has been invited as speaker for many of local educational programs and conferences as well Gulf, Arab and international conferences. He developed interest in medical education and he had Certificate of medical education- university of Illinois, Chicago, USA 2009. In research he has published more than 40 publications in refereed journals and orally presented more than 60 presentations in international meetings. He has also authored an English textbook of Pediatric Endocrinology and diabetes textbook, and 10 Arabic books. Finally, he is a member of many of Pediatric and Endocrine local and international societies. Abdulmoein Al Agha is a Professor of Pediatrics & Pediatric Endocrinology at King Abdul Aziz University. He received his Fellowship certificate in Pediatric Endocrinology and Diabetes from Sydney, Australia, 2001. Fellowship of the Royal College of Physician (Edinburg) since 1997, and graduated King Abdul Aziz University Medical School, Jeddah, Saudi Arabia, 1991. He has many present and past academic and administrative positions including; MRCPCH Overseas examiner and host as well supervisor for Saudi Board Pediatric residency training for western Region since 2001. He is a coordinator, Pediatric Club Western Region, since 2007 to present. He is the chairman of Reproductive Modules "New Faculty Curriculum" from 2009 to present. He was acting Chairman, of Pediatric, KAUH 2006-2007. He is as well, a visiting instructor and teacher, Ibn- Sina Medical School, 2008 to present. He has been invited to be an external examiner for many of Gulf and Arab countries; including Bahrain, Kuwait, United Arab Emirates, Oman, and Egypt for Pediatric under and post graduates as well for Endocrine examinations. He has been invited as speaker for many of local educational programs and conferences as well Gulf, Arab and international conferences. He developed interest in medical education and he had Certificate of medical education- university of Illinois, Chicago, USA 2009. In research he has published more than 40 publications in refereed journals and orally presented more than 60 presentations in international meetings. He has also authored an English textbook of Pediatric Endocrinology and diabetes textbook, and 10 Arabic books. Finally, he is a member of many of Pediatric and Endocrine local and international societies.



    Abstract
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    Abstract

    Abdulmoein Eid Al-Agh
    King Abdul Aziz University, Saudi Arabia

    Obesity and overweight among children and adolescents is increasing at an alarming rate, which lead to the increase in the incidence of their related co-morbidities. Our objectives are to establish the following: 1) the prevalence of hyperinsulinism among overweight and obese pediatric patients. 2) The prevalence of type 2 diabetes mellitus (T2DM) among those with hyperinsulinism. 3) The prevalence of metabolic syndrome (MS) and its components among T2DM pediatric patients. A retrospective cross-sectional study conducted on overweight and obese pediatric patients attending the pediatrics diabetes clinic at King Abdul-Aziz University Hospital, Jeddah, Saudi Arabia, from 2006 to 2010. Serum insulin level was measured for 387 patients (ages from 2 to 18 years). Those with hyperinsulinism underwent further investigations to assess the prevalence of T2DM and the prevalence of MS among T2DM patients. The overall prevalence of hyperinsulinism and T2DM were 44.7%, and 9.04%, respectively. Among children and adolescents with T2DM, 62.86% had a body mass index BMI≥85th percentile, 37.14% had a BMI ≥ 95th percentile, 14.29% had MS, 34.29% were hypertensive and 28.57% had dyslipidemia. Obesity and its co-morbidities were prevalent among Saudi pediatric patients. We recommend preventing excessive weight gain through the promotion of a healthy lifestyle, family educational seminars and the reinforcement of indoor exercises

    Time:

    Title: Incidence and reasons of sleeve gastrectomy conversion

    Sami Salem
    Jordan Hospital, Jordan

    Biography
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    Biography

    Sami Salem
    Jordan Hospital, Jordan



    Abstract
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    Abstract

    Sami Salem
    Jordan Hospital, Jordan

    BACKGROUND: Laparoscopic sleeve gastrectomy is increasing worldin the last years. We see more cases in the last years who need conversions for different reasons. Common reasons are dissatisfaction of the patients or complications. We observed the reasons of conversion in our clinical practice METHODS: between 2002-2016. we have performed 1220 operations. 990(81%)patients were available for follow up.We collected our data prospectively. Recorded data preoperatively included age, sex, comorbidity, body mass index (BMI),Postoperatively recorded data included, intra and post operative morbidity and mortality, percentage of excess weight loss (%EWL), re-interventions and conversion to other procedure, patients who had the primary sleeve operation by other surgeons and came for second procedure were included in the converted group. RESULTS: we had 122 redo or conversion operations. 24 of them from my clinic and 98 from other clinics. Indication of conversion or redo was insufficient weight loss in 47(38.5%), severe reflux disease in 48,(39%), gastric stricture in 23(18.8%), fistula and leakage 4(0.3%). Procedures performedlaparoscopically were re-sleeving in 18 cases, omega bypass in 89 cases, Roux en Y gastric bypass in 14 cases biliopancreatic diversion in 2 cases. Satisfaction of the re-operated cases was achieved in 90% of the cases in longer than one year follow up. CONCLUSIONS:Insufficient weight loss and gastroesophageal reflux disease are the common indications for sleeve gastrectomy conversion and different options are available.The majority of the patients are satisfied with conversion results.

    Time:

    Title: Duodenal Resurfacing Procedure A Novel Approach for Type 2 Diabetes Management

    Mahir Ibrahim Jallo
    Gulf Medical University, UAE

    Biography
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    Biography

    Mahir Ibrahim Jallo
    Gulf Medical University, UAE

    Dr. Jallo is a Clinical Professor of Medicine and Consultant Endocrinologist in Gulf Medical University GMU in UAE & Faculty in the Canadian Academy of Natural Health. Granted his MBChB from Mosul Medical College in IRAQ, postgraduate Board Certification in Internal Medicine CABM (PhD Equivalent) from the Arab Board, Fellowship of the American College of Endocrinology FACE & certified with Diploma in Dyslipidemia from Boston University School of Medicine from USA . He was an Affiliated Faculty in the Department of Medicine, Mosul Medical College & Department of Clinical Pharmacy, Mosul College of Pharmacy in IRAQ till 2004. He is actively involved as an inviting speaker in many National & International conferences & CME programs. He is the organizer of the annual GMU Diabetes & Endocrinology Conference, and organizing committee member of many international conferences. Editor In Chief: Diabetes Digest from Iraq, Editorial Board Member & reviewer for many international Diabetes & Endocrinology journals, with many publications in medical periodicals and medical conferences abstract & Active Principle Investigator in many National & International Clinical studies. He is a member of many national & international medical societies & associations



    Abstract
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    Abstract

    Mahir Ibrahim Jallo
    Gulf Medical University, UAE

    Bariatric surgery has emerged as an effective intervention to treat obesity and its related co morbidities. For multitude of factors, access, insurance, patient fears, referrals and the procedures risks, only 1% of the eligible undergoes bariatric surgery. Considerable needs for effective nonsurgical treatment modalities are mandated. The minimally invasive novel endoscopic therapies with less morbidity could be the answer for many morbidly obese patients. Researches advocate the important role of the foregut in the regulation of glucose homeostasis & diabetes. A novel purely endoscopic catheter based procedure that targets the duodenal mucosa had been developed by Fractyl Laboratories targeting the abnormal hypertrophy and hyperplasia and the alterations in the enteroendocrine cells of the foregut usually seen in patients with diabetes. This minimally invasive Duodenal Mucosal Resurfacing System DMR is known as Revita. Revita involves 2 main steps: First, creation of a protective barrier by lifting the sub mucosal space of the duodenum with endoscopic injection of saline and second, hydrothermal ablation (recirculation of hot water within a balloon tipped catheter) of the circumferential duodenal mucosa. This rejuvenation of the lining of the duodenum will change gut signaling in patients with metabolic diseases caused by insulin resistance. The early results with Revita DMR are quite encouraging, with well tolerated procedure, concerning safety, three instances of duodenal stenosis was reported, and treated using endoscopic balloon dilation. The 1st study involving 39 T2 DM who were failing oral medications, at 6 months, the treatment had improved glycemic control, with significant decrease in FBG, PPG, and HbA1c. The patients receiving DMR on a long segment (average 9.3 cm, n 28) compared to short (average 3.4 cm, n 11) of the duodenum experienced a greater reduction in HbA1c levels at 3 months and achieved a reduction in HbA1c levels from 8.5% to 7.1% at 6 months & about 5 pounds of weight loss. Further studies are necessary to understand the core mechanism, long term safety, efficacy, durability and how the procedure performs in a randomized clinical trial setting, while also embracing the potential for wider metabolic benefits.

    Time:

    Title: Laparoscopic gastric plication; why we stopped doing it

    Ahmed Elgeidie
    Mansoura University, Egypt

    Biography
    χ

    Biography

    Ahmed Elgeidie
    Mansoura University, Egypt



    Abstract
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    Abstract

    Ahmed Elgeidie
    Mansoura University, Egypt

    Background. Laparoscopic gastric plication (LGP) is one of the restrictive bariatric procedures. It seemed attractive to both morbidly obese patients and bariatric surgeons due to two main factors; safety and low cost. Moreover, many studies documented its efficacy in terms of weight loss and resolution of comorbidities. This study tests the mid-term outcome of LGP in morbidly obese patients. Patients and methods. The data of morbidly obese patients who underwent LGP were analyzed. LGP was offered to obese patients with BMI > 40 kg/m2 or > 35 kg/m2 with one or more comorbidities. Superobese patients (BMI > 60 kg/m2) and those who have previous bariatric surgeries were excluded. The technique of LGP was standardized. After gastric mobilization the stomach was plicated in two rows of extramucosal non-absorbable sutures over 36 Fr calibrating tube. Perioperative and in-hospital data were recorded. Postoperative follow up visits was scheduled at 1, 3, 6, 12 months then annually. Patients were followed for complications, weight loss and resolution/improvement of comorbidities. Results. Eighty eight consecutive morbidly obese patients had been operated by the standardized technique of LGP between March 2010 and September 2014. There were 19 men and 69 women, with a mean age of 24.2 years and a mean BMI of 38.7 kg/m2 (range 35 to 51 kg/m2). Type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, and back pain were reported in 4, 10, 12, 4, 6 patients respectively. There were no significant intraoperative complications and no conversion to laparotomy. The most frequently reported complication was prolonged early postoperative nausea/vomiting and occurred in 5 of 88 (5.7 %) patients and were treated with conservative means. Early leak occurred in 3/88 (3.4%) patients and it was managed by conversion to laparoscopic sleeve gastrectomy (LSG) in two patients (one of them died of sepsis) and suture repair with undoing plication in the last patient. Postoperative follow-up period ranged from 6 to 42 months with a mean of 25 months. %EWL was 27.2 %, 35.0 %, and 41.1 % at 3, 6, and 12 months, respectively. Weight regain had been reported in 10 (11.4%) patients at a mean follow up period of 9.5 months. It was treated by laparoscopic replication (n=2), conversion to LSG (n=1), laparoscopic minigastric bypass (MGB) (n=1). One of replicated patients had inadequate weight loss and was converted to laparoscopic MGB. Resolution/improvement of comorbidities was documented in 5/36 (13.9%) patients only. Conclusions. Inadequate weight loss, prolonged hospital stay, inadequate resolution/improvement of comorbidities plus risk of leak forced us to stop LGP. However, more studies on a larger number of patients with longer follow up is required. Key words. Laparoscopic gastric plication, bariatric surgery, leak, weight regain, morbid obesity

    Time:

    Title: Association of asymptomatic neuroendocrine tumour with rapid-onset obesity, hypoventilation, hypothalamic dysfunction, and autonomic dysfunction (ROHHAD) syndrome

    Asmaa Adel Milyani
    King AbdulAziz University, Saudi Arabia

    Biography
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    Biography

    Asmaa Adel Milyani
    King AbdulAziz University, Saudi Arabia

    Asmaa Milyani is a 21year old medical student in her final year of medical school at King AbdulAziz University. With a recognisable merit in literature since childhood, and having always been an advocate for science with a strong belief in the moral pillars of Medicine, she aspires to further pursue her clinical practice in Paediatrics with great passion and achievement in research.



    Abstract
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    Abstract

    Asmaa Adel Milyani
    King AbdulAziz University, Saudi Arabia

    The rapid onset of obesity in the setting of hypoventilation, hypothalamic dysfunction and autonomic dysfunction constitutes the syndrome of ROHHAD NET, with some cases presenting with a neuroendocrine tumour. It is a rare fatal disease due to respiratory failure that necessitates the early recognition and consequent provision of ventilatory support to improve outcome. Keywords: Obesity, Hypothalamic, Autonomic, Dysfunction, Neuroendocrine

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