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International Conference on
Obesity and Weight Loss

November 6-8, 2017 | Barcelona, Spain

Program Schedule

  • Keynote Speaker

    Time:

    Title

    Title: Obesity and Heart Failure the two Pandemics of our Days

    E.Radzishevsky
    Heart Failure Center, Israel
    Biography
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    Biography

    E.Radzishevsky
    Heart Failure Center, Israel

    Eugeny Radzishevsky is a Head of Herat Failure Center, Clalit Health Services, IL. He completed academic Degree MD, 1990-1996 University of Medicine Kharkov, Ukraine. Professional Experience in 1996 -2011-Cardiology training, Bnai Zion Medical Center & Faculty of Medicine, Technion, Haifa, IL In 2011 worked as a Senior Cardiologist, Dept. of Cardiology, Bnai-Zion Medical Center.



    Abstract
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    Abstract

    E.Radzishevsky
    Heart Failure Center, Israel

    Obesity and Heart Failure Recent Trends Obesity and Heart Failure The Two Pandemics of Our Days. Dr. E.Radzishevsky In a recent study the risk of developing future heart failure (HF) among >1.5 million young men was nine times higher in the highest BMI category (≥35 kg/m2) compared with those with normal BMI. With regards to the WHO estimation that 50% of adults in Europe are overweight or obese, the magnitude of problem is obvious. Which impact has obesity on the cardiovascular system and what do we know about the direct effects of obesity on the myocardium and developing HF in this lecture I'll try to show the association between high BMI and developing of HF through the prism of the coronary artery disease and via the direct effects of obesity on the heart, like increasing blood volume with high cardiac output, changes in pressure volume loop in the left ventricle, etc. From immunological point of view, the relationship between obesity and HF goes through the inflammatory cascade and the pathological level via cardiac steatosis which is a consequence of obesity, so discussion about recent findings in this field is mandatory. Obesity is common in HF with preserved ejection fraction as well as with subclinical ventricular dysfunction has been proved recently. Thus, if obesity is related with preserved EF% HF is a distinct entity of heart failure does is require specific treatment The traditional three categories of treatment options, drugs, physical activity and surgical treatment will be discussed with emphasis on studies concerning physical activity and bariatric surgery impact on chronic sub clinical myocardial damage HF incidence. Finally, the significance of BNP as prognostic and diagnostic marker in HF, as well as the issue of the Obesity Paradox will be discussed.

    Keynote Speaker

    Time:

    Title

    Title: Modulation of Gut Microbiome - from Phenomenology to Dietary Recommendations to Tackle Obesity

    Stoffer Loman
    NutriClaim, Netherlands Biography
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    Biography

    Stoffer Loman
    NutriClaim, Netherlands

    Stoffer has acquired a BSc-degree in Tropical Agriculture at the Royal Dutch College for Tropical Agriculture (Deventer, the Netherlands, was trained a Nutritionist (MSc) at Wageningen University (1992) and has obtained his PhD in Medical Sciences/Immunology at the Academic Medical Centre of the University of Amsterdam/ (1998). Following a career in the food supplement industry as science communicator and health educator he founded NutriClaim in 2007 (www.nutriclaim.com), providing specialist services pertaining to the scientific substantiation of health claims made on food, and in the marketing authorization of Novel Foods in the EU. Currently, Stoffer is also Work Package Leader in the EU FP7-funded project My New Gut



    Abstract
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    Abstract

    Stoffer Loman
    NutriClaim, Netherlands

    The potential role of intestinal microbiota in the etiology of various human diseases has attracted massive attention in the last decade. Experiments in animal models have produced evidence for a causal role of intestinal microbiota in the etiology of obesity and insulin resistance. However, with a few exceptions, such causal relation is lacking for humans and most publications merely report associations between intestinal microbial composition and metabolic disorders such as obesity and type 2 diabetes. Dietary recommendations are generally based on epidemiological evidence of an association between a food, food component or diet with the prevalence of a disease. However for microbiome-targeted dietary recommendations, little or no epidemiological evidence is available. In fact, world-wide no microbiome-related dietary recommendations have been proposed. Nevertheless, diet-induced changes in the microbiota have been shown to be associated with insulin resistance and development of diabetes. However, it is as yet an enigma as to which extend the altered microbiota is causally related to insulin resistance and diabetes or whether these changes in the microbiota are secondary to the development of insulin resistance and diabetes, the latter two induced by non-microbiota dependent pathophysiological mechanisms. Thus, the reciprocal relationship between the gut bacteria and these metabolic disorders remains a matter of debate. In addition, and in particular with respect to fiber, the health benefits of its consumption may be conferred even without the apparent involvement of the microbiome. In particular, e.g. studies into the role of fiber in its capacity to modify the microbiota to confer a health benefit have until now solely relied on measuring the changes in the microbiota at the start and completion of the study. Therefore, changes in the microbiota by itself are not sensitive enough to provide for a causal explanation of the observed metabolic effects. Unless multiple time points are included in the study design, kinetic of changes in the microbiota, combined with simultaneously revealing the kinetics of gene, protein and metabolome expression, applying multiple -omics techniques, microbiome-targeted dietary recommendations will remain elusive.

    Keynote Speaker

    Time:

    Title

    Title: Effects of Natural Medicines Kalonji, Honey versus Standard Chemical Atorvastatin on the Blood Lipid Profile of Hyperlipidemic Obese Patients

    Farid Menaa
    California Innovations Corporation and Fluorotronics Inc., USA Biography
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    Biography

    Farid Menaa
    California Innovations Corporation and Fluorotronics Inc., USA

    Dr. Menaa is an multidisciplinary professional with a holistic concept to solve health issues and biosystems limitations. His strong academic background is completed by many years experiences in prestigious organizations. In 2009, Dr. Menaa was promoted to CSO and R&D&I EVP for Fluorotronics, Inc, USA, where he co-developed and translated an innovative green technology called SpectroFluor. In 2013, he successfully organized the 1st world Nanomedicine and Nanobiotechnology Conference http://www.targetmeeting.com; 2013). Consultant, Teacher, Event Organizer, Researcher, Reviewer and Editor of reputed journals, including in nutrition, he has also authored more than 100 scientific articles and participated to over 200 scientific events.



    Abstract
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    Abstract

    Farid Menaa
    California Innovations Corporation and Fluorotronics Inc., USA

    Hyperlipidemia refers to the excess of lipids in the bloodstream, and is characterized by diverse lipid profiles (e.g. hypercholesterolemia, hypertriglyceridemia, familial combined hyperlipidemia) that often lead to undesirable health effects such as obesity. Randomized controlled clinical trial was conducted to compare the effects of Kalonji and Honey with Atorvastatin (Lipitor) on the lipid profile of a large cohort of hyperlipidemic patients with moderate to severe central obesity. Sixty male informed consent patients aged from 35 to 65 years (47.409.10) were enrolled for a study period of 30 days. They were randomly divided into three equal groups. Group 1 was treated with 2 g of Kalonji seed; Group 2 was given one tablespoon of pure Honey; and Group 3 was treated with 10 mg per morning day of Atorvastatin. Fasting baseline laboratory values at time 0 (i.e. before treatment) were obtained for all parameters (i.e. TC, LDL-c, HDL-c, TGs) on each subject prior to the study start. The plasmatic parameters were then assessed enzymatically at 15 days and 30 days after treatment, normalized with the baseline values, and the end point values submitted to between-group statistical analyses. Interestingly, all three medicines significantly lowered (p 0.05) TC, LDL-c, and TGs levels. Conversely, any of the three treatments showed significant increase in HDL-c levels. These effects were improved in a time-dependent manner, except for Honey. Globally, after 15 and 30 days of treatment, the best reduction in TC, LDL-c and TGs levels was obtained with Kalonji. However, Atorvastatin was found more effective on HDL-c levels after 15 and 30 days of treatment. Thus, comparative effects of Kalonji or Honey with Atorvastatin showed relative and time-dependent effectiveness in reducing TC, LDL, TGs and increasing HDL-c, and suggest that these natural medicines could be used to improve the outcome of adult obese patients suffering from hyperlipidemia. Keywords: Obesity; Hyperlipidemia; Kalonji; Honey; Atorvastatin; Alternative and complementary medicine.

    Sessions:
    Genetics of Obesity & Ties between Obesity and Diabetes & Dietary Supplement, Nutrition & Healthy Lifestyle & Obesity and Oncology & Obesity and Weight Management

    Time:

    Title: The Effect of a Structured Exercise Program on Obese African American Participants Physical and Psychological Health

    Lakina Moseley
    Wayne State University, USA

    Biography
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    Biography

    Lakina Moseley
    Wayne State University, USA

    Lakina Moseley, DHEd, is an adjunct professor at Wayne State University for the Division of Kinesiology, Health and Sport Studies. Her areas of expertise are exercise and nutrition, physical education, health education, and aquatics. Her research interests are obesity prevention and treatment, physical activity and nutrition behavioral intervention, and exercise motivation and adherence. Dr. Moseley is also the owner of Destination Fitness, which provides individualized exercise programs to her clients. She holds a bachelors in kinesiology and a masters in the art of teaching from Wayne State University. She also holds a doctorate in health education from A.T. Still University



    Abstract
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    Abstract

    Lakina Moseley
    Wayne State University, USA

    Obesity is a global epidemic affecting millions of people. It leads to a myriad of health problems with the most serious being death. By increasing physical activity, obesity can be reversed and or prevented. The purpose of this study was to determine how having a structured exercise program affects overall physical activity and psychological health. Specifically, this investigation examined how body image, self efficacy and motivation would affect overall physical activity. Using a mixed-method design, subjects were evaluated using pre and post intervention surveys on physical activity, self-efficacy, body esteem and motivation. Results showed that there was a significant difference in self efficacy, motivation and male body esteem when comparing their post-intervention scores to their pre-intervention scores. However, there was no significant difference in the three phases of overall physical activity or female body esteem. Although there was no significant difference in overall physical activity, the results show it was trending in a positive direction. The small sample size, study duration, physical activity assessment may have influenced the results. Even though there was no significant difference in overall physical activity or female body esteem, a structured exercise program appears to be promising tool for increasing overall physical activity and psychological health. Keywords: Body esteem, motivation, self-efficacy, physical activity, structured exercise program, obesity, African American, psychological health, Health Belief Model, Logic Model

    Time:

    Title: Association of Asymptomatic Neuroendocrine Tumor with Rapid-onset Obesity, Hypoventilation, Hypothalamic Dysfunction, and Autonomic Dysfunction (ROHHAD) Syndrome

    Asmaa Adel Milyani
    King AbdulAziz University, Saudi Arabia

    Biography
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    Biography

    Asmaa Adel Milyani
    King AbdulAziz University, Saudi Arabia

    Asmaa Milyani is a 21year old medical student in her final year of medical school at King AbdulAziz University. With a recognisable merit in literature since childhood, and having always been an advocate for science with a strong belief in the moral pillars of Medicine, she aspires to further pursue her clinical practice in Paediatrics with great passion and achievement in research.



    Abstract
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    Abstract

    Asmaa Adel Milyani
    King AbdulAziz University, Saudi Arabia

    The rapid onset of obesity in the setting of hypoventilation, hypothalamic dysfunction and autonomic dysfunction constitutes the syndrome of ROHHAD-NET, with some cases presenting with a neuroendocrine tumour. It is a rare fatal disease due to respiratory failure that necessitates early recognition and consequent provision of ventilatory support to improve outcome. We report the recognition of a second case of ROHHAD-NET syndrome in Saudi Arabia.

    Time:

    Title: Meet Moringa: A Superfood for Metabolic Resilience

    Carrie Waterman
    UC Davis, USA

    Biography
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    Biography

    Carrie Waterman
    UC Davis, USA

    Dr. Carrie Waterman is an interdisciplinary research scientist at the intersection of nutrition, agriculture, health and development. She received her PhD in Pharmacognosy and spent the following years as a post doc in Natural Products Chemistry. She was a Fulbright Scholar at the University of Nairobi, Kenya and served as a Peace Corps volunteer in West Africa. She is currently a Professional Research Assistant in Nutrition at UC Davis with a NIH Fogarty International K01 grant. She is working with in Kenya on moringa, a plant used to treat malnutrition and prevent chronic diseases including diabetes and obesity.



    Abstract
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    Abstract

    Carrie Waterman
    UC Davis, USA

    Moringa (Moringa oleifera Lam.) is an edible plant used as superfood and medicine throughout the tropics. A moringa concentrate (MC) was made by extracting fresh leaves with water utilized naturally occurring myrosinase to convert the glucosinolatesintochemically stable moringa isothiocyanates (MICS). MC and MICs significantly decreased inflammatory makers and glucose production in vitro. MC, supplemented in the diet at 5%, significantly reduced pathologies of metabolic syndrome in diet-induced obese C57 mice; MC-fed mice exhibited reduced weight gain and lower levels of insulin, leptin, inflammatory markers, liver damage, and cholesterol. Our results suggest a potential for stable and concentrated moringa isothiocyanates, delivered in MC as a nutritious food-grade product, to alleviate low-grade inflammation associated with chronic diseases and malnutrition. Future studies will evaluate the nutrient and MIC content of moringa varieties present in Kenya and mechanistic studies to understand the role of MC and MIC in diabetes and obesity prevention.

    Time:

    Title: Insulin Resistance - Linking modulation of the Gut Microbiome to Dietary Recommendations and Health Claims

    Stoffer Loman
    NutriClaim, Netherlands

    Biography
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    Biography

    Stoffer Loman
    NutriClaim, Netherlands

    Stoffer has acquired a BSc-degree in Tropical Agriculture at the Royal Dutch College for Tropical Agriculture (Deventer, the Netherlands, was trained a Nutritionist (MSc) at Wageningen University (1992) and has obtained his PhD in Medical Sciences/Immunology at the Academic Medical Centre of the University of Amsterdam/ (1998). Following a career in the food supplement industry as science communicator and health educator he founded NutriClaim in 2007 (www.nutriclaim.com), providing specialist services pertaining to the scientific substantiation of health claims made on food, and in the marketing authorization of Novel Foods in the EU. Currently, Stoffer is also Work Package Leader in the EU FP7-funded project My New Gut



    Abstract
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    Abstract

    Stoffer Loman
    NutriClaim, Netherlands

    Obesity is one of the greatest public health challenges of the 21st century. Its prevalence has tripled in many countries of the World Health Organization (WHO) European Region since the 1980s, and the numbers of those affected continue to rise at an alarming rate. In addition to causing various physical disabilities and psychological problems, excess weight drastically increases a persons risk of developing a number of non-communicable diseases), including cardiovascular disease, cancer and diabetes. Worldwide, current dietary recommendations dont refer to the role of the gut microbiome in health. Nevertheless, from a public health perspective, establishment of a physiologically relevant, beneficial health effect following modification of the microbiome on obesity should best be established by the favourable modification of one common denominator that is directly linked to a physiological beneficial effect. As common denominator of studies into the dietary modulation of the microbiome by probiotic and prebiotic foods, insulin resistance has been proposed. Not only is insulin resistance a hallmark in the development of obesity and type 2 diabetes, but it is also implicated in a plethora of disease states and diseases associated with metabolic syndrome, like excessive weight, hypertension, atherogenic dyslipidemia and chronic low-grade inflammation. This notion implies that insulin resistance should be one of the important, if not the most important primary outcome measure in clinical studies, applying pre- and probiotic interventions and performed in the context of applied microbiome research. Taken together, in order to make the shift from microbiome research towards its application in dietary strategies and recommendations, as well as into health claims made on newly developed microbiome-modifying foods, we hypothesize that microbiome research should, at least in part, be targeted at deciphering the impact of (un)favourable modulation of the microbiome on insulin resistance.

    Time:

    Title: Role of Nutrition and Nutraceuticals in Preventing Obesity

    TheerthamPradyumna Rao
    Taiyo Kagaku Co Ltd, Japan

    Biography
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    Biography

    TheerthamPradyumna Rao
    Taiyo Kagaku Co Ltd, Japan

    Dr T.P.Rao has completed his PhD and postdoctoral studies at Nagoya University, Japan and a certificate course in International Food Laws and Regulations at Michigan State University, USA. He is General Manager at Taiyo Kagaku, Japan. He started his career at ICRSAT (International Crop Research Institute for Semi-Arid Tropics, India) and acquired extensive research, marketing and regulatory experience ranging in the fields of agriculture, nutrition to health. He has published one book and more than 65 papers in reputed journals and books. He has been serving as an editorial board member of NutraCos magazine and Austin Journal of Nutrition and Metabolism.



    Abstract
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    Abstract

    TheerthamPradyumna Rao
    Taiyo Kagaku Co Ltd, Japan

    The prevalence of obesity may differ with age, ethnic background and economic conditions. However, the health implications associated with obesity were nevertheless same. Although the genetic factor may cause the obesity, the behavioral influence such as diet, physical activity and environmental factors have stronger influence on the prevalence and propagation of obesity. Therefore the energy balance in the intake and use of calories by the body plays a critical role in weight gain. Several healthy diet guidelines recommends eating veggie and low fat diets but excess intake of the same may again cause energy imbalance and therefore is less effective in preventing the weight gain. On the other hand nutraceuticals such as green tea, Garcinia combogia, Coleus forskohilli, fucoxanthinetc and supplements like Acetyl l-carnitine, 5-HTP and CLA etc are exhibited to be effective in fat burning and weight loss in adult populations. Maintenance of regular energy balance is the strategical and logical approach such as limiting the calories from the daily diet and increasing the pysical activity must be observed as routine and with the aid of nutraceuticals may effectively prevent the prevalence of obesity in both children and adults. Nutraceuticals targeting weight control alone does not support overall improvement, but rather a comprehensive approach tackling glucose metabolism, fat burning and circulation may require to counter obesity and related complications. A number of nutraceuticals are recommended for weight management while providing a proper nutritionalbalance

    Time:

    Title: The Effects of A Combined Exercise Programme Aerobic and Resistance or Resistance Alone or Aerobic Alone on Blood Glucose, Incretin, Metabolic and Inflammatory Mediator that could Control the Diabetes and Increase Insulin Sensitivity in Type 2 Diabetes

    Nawal Alsubaie
    De Montfort University, UK

    Biography
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    Biography

    Nawal Alsubaie
    De Montfort University, UK

    Nawal Hamad completed her MSC. Degree (Clinical Pharmacy International Practice and Policy) and currently she works as a Clinical Pharmacist, Prince Sultan Military Medical City, (PSMMC).



    Abstract
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    Abstract

    Nawal Alsubaie
    De Montfort University, UK

    An excessive number of calories consumed daily, in addition to a sedentary lifestyle, are the main causes of increasing type 2 diabetes (T2D) prevalence worldwide (LEE, H.K. et al., 2010). Diabetes usually accompanied by hypertension, lipid disorders and obesity. Recent studies show that the reduction in HbA1c cause 35% relative risk reduction for fatal/nonfatal cardiovascular disease. Also 56% reduction in CVD when this reduction of HbA1c accompanied with systolic blood pressure (SBP) decrease. Moreover, 75% reduction in CVD if reduction of HbA1c and SBP accompanied with decrease in non-HDL level (Eeg-Olofsson et al., 2016). The aim of this study to prove that combination exercise is better than aerobic or resistance alone. It is going to compare T2D and ND who are doing combination exercise with same study groups who are doing either aerobic or resistance training. Moreover, it is going to compare the intervention group with control group of both T2D and ND who are following sedentary life style. All these comparisons to show if the changes in primary and secondary outcome are significant between the different groups. This study is also looking for the changes in incretin level in all groups to see if there is any effect of exercise on the secretion of this hormone and compare it to T2D who are using different medication for diabetes. T2D is considered as a serious disease, which needs immediate intervention. This intervention depends on the severity of the case. It could be either diet and exercise or pharmacological intervention by using anti-diabetic medication or insulin to control blood glucose levels within normal levels. It is necessary to check routinely to discover T2D at an early stage because identification and early treatment can prevent further complications in pre-diabetes or metabolic disorder. Diet and exercise can potentially prevent the development of T2D of many of those at risk or in early stages (Diabetes UK, 2016). Research questions 1- Are there demonstrable health differences after the six weeks exercise intervention? 2- Does exercise change glucose and lipid derangements? 3- Does exercise affect the inflammatory nature of T2D? 4- Are the metabolic and inflammatory profiles related? 5- Do the improvements correlate with medication type? 6- Do the improvement affect incretin involvement? Conclusion In T2D and ND combination exercise has significant effect on HbA1c, and the anthropometric variables (weight, waist, BMI and lung capacity). Previous studies and researchers had evaluated the effects that aerobic training and resistance training had on the glycaemic control in term of HbA1c in patients suffering from T2D (Sigal et al., 2007); (Yavari et al., 2012). This study shows reduction in BG after aerobic exercise more than after resistance, which illustrate that, performing resistance exercise before aerobic exercise improved glycaemic control during exercise (Yardley et al., 2013). OGTT shows a very significant improvement of BG level in both groups, that was higher in T2D. This suggests that combination exercise is valuable in improving insulin sensitivity in T2D. It was concluded that the combination exercise was the best exercise for improvements to insulin resistance (Davidson et al., 2009)

    Time:

    Title: Physical Inactivity, Body Composition and Obesity Risk among Young Adults

    Cristiana Lucretia Pop
    Bucharest Economic Studies University, Romania

    Biography
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    Biography

    Cristiana Lucretia Pop
    Bucharest Economic Studies University, Romania

    Dr. Cristiana Lucretia Pop is Professor at the Bucharest Economic Studies University, Physical Education and Health Department. Her research interests include: overweight and obesity risk assessment, well-being, quality of life, and promoting physical activity and a healthy lifestyle. She is member of Romanian Agency for Quality Assurance in Higher Education, member of Romanian Athletic Federation (women commission) and has research collaboration with Romanian Academy, Anthropological Institute Research Center. She is Senior Editor and Editorial Board Member of several reviews in education, health and sport sciences domain.



    Abstract
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    Abstract

    Cristiana Lucretia Pop
    Bucharest Economic Studies University, Romania

    Obesity and physical inactivity seem to have a common evolution and a reciprocal determination with disastrous combined effects on morbidity and mortality. Beside an average increase of weight and the predisposition to overweight and obesity, a decrease in fitness level and skills is observed in the newest generations. The excessive energy intake combined with the decreasing energy expenditure contribute to a concerning balance between fat and lean body mass even in young people. The weight management quantitative issues tackled in this research are weight, body mass index and body composition. The main research question is if the ratio between body fat and muscle mass could return different results regarding overweight and obesity risk, comparing with BMI results? While by calculating BMI the estimated number of overweight and obese subjects was of 14 %, by measuring body fat percentage that number increased to 43% of the young women (19-24 years) in the research sample. The t test returns a significant difference between BMI values and the body fat percentage for the study sample: t (155) = 2.37; p<0,01. The conclusion is that BMI results may be insufficient for a correct estimation of overweight and obesity risk. The body composition adds useful information about health and fitness status. Considering that muscle mass is decreasing with age, promoting physical activities in preschools, schools, universities and among adults through active transportation, spending time or exercising outdoors as leisure time, or joining sport competitions in a proper environment could prevent sarcopenic obesity. Integrating physical and health education in overweight preventative strategies would have effect in reducing the occurrence of physical and emotional disorders and co-morbidities over the lifetime.

    Time:

    Title: Genetics and Epigenetics Markers of Adiposity toward Precision Medicine

    Amelia Marti
    University of Navarra, Spain

    Biography
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    Biography

    Amelia Marti
    University of Navarra, Spain

    Amelia Marti is a Professor in Human Physiology, University of Navarra, Pamplona (Spain). Prof. Marti has received the Silver Medal of the British Society for Nutrition, the Merck & Daphne Award, the award of the NAOS Spanish Strategy, the European Prize for the Best Doctoral Thesis supervised in Obesity. Her research in the field of nutrition and obesity, with more than 229 scientific publications and H factor = 37 (Web of Science). Expert in the Board of the Spanish Society for Obesity.



    Abstract
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    Abstract

    Amelia Marti
    University of Navarra, Spain

    Advances in genetics and epigenetics have resulted in the identification of about 100 and 200 loci respectively, related to human adiposity. FTO gene variants are the most replicated and showed the highest statistical significance. However, despite these advances, the combined effect of genome identified so far account for about 5% of the inherited contribution to obesity risk (40 to 70). These statistics confirm the complex nature of obesity and the need to identify additional factors including (epi)genetic markers and also their interactions with environmental factors. The OMICs technologies could help to study genetic predisposition (genome), and changes in epigenetics (epigenome), gene expression (transcriptome), proteins (proteome), and metabolites (metabolome) to further improve prevention, diagnosis and treatment of obesity and related complications. Here I will present some examples of the importance of genetic and epigenetic markers when studying the response to nutritional interventions such as: the PREDIMED Navarra study (based on a Mediterranean diet pattern in high cardiovascular risk subjects), and the EVASYON study (a weight loss program for Spanish obese adolescents).

    Time:

    Title: Anti-obesity effect of Physagulin-F isolated from Physalis angulatafruits in lean rats fed a high fat diet

    Estari Mamidala
    Kakatiya University, India

    Biography
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    Biography

    Estari Mamidala
    Kakatiya University, India

    Dr,EstariMamidala completed his under graduation and post-graduation from Kakatiya University. He did Ph.D in Zoology Department, Kakatiya University, India. He awarded DBT rapid grant young investigator award. After the completing of his Ph.D he was selected as Fast Track Young Principal Investigator from DST, New Delhi. Now he is doing post-doctoral research. He published more than 15 research publications in reputed journals.



    Abstract
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    Abstract

    Estari Mamidala
    Kakatiya University, India

    Background: The search for new alternative and effective treatment methods were ongoing for obesity which is worldwide epidemic that reduces life expectancy. The present study aimed at investigating anti-obesity potential of physagulin-F isolated from Physalis angulata fruits. Methods: The rats were randomly divided into six groups i.e., (1) Normal Diet (2) Normal Diet with 50 mg/kgBW of physagulin-F (ND + 50 mg/kgBW); (3) Normal Diet with100 mg/kgBW of physagulin-F (ND + 100 mg/kgBW); (4) High Fat Diet (HFD); (5) High Fat Diet and 50 mg/kgBW of physagulin-F (HFD + 50 mg/kgBW); (6) High Fat Diet and 100 mg/kgBW of physagulin-F (HFD + 100 mg/kgBW). Through analyses of changes in body weight, visceral fat weight and blood biochemicals like total cholesterol, triglycerdies, HDL-C, LDL-C, insulin, adipoectin, leptin and fecal fat content anti-obesity potential was evaluated. Results: Rats receiving physagulin-F together with HFD showed significant (p < 0.05) reduction in body weight gain compared to rats receiving HFD only. At the end of study, the body weight gain of physagulin-F treated rats was not significantly (p > 0.05) different with those of normal diet rats. plasma lipid profiles, insulin, leptin, and adiponectin like obesity biomarkers levels also showed significant improvement (p < 0.05). Administration of physagulin-F caused significant (p < 0.05) increase in fecal fat excretion, which validates the hypothesis of lipase inhibition, similar to standard drug of Orlistat. Conclusion: This study concludes that the physagulin-F isolated from P. angulata fruits showed anti-obesity properties by inhibition of intestinal lipid absorption and also by modulation of adipocytes markers.

    Time:

    Title: Fractalkinea as an inflammatory marker in obese subjects

    Mohsen Khalid
    Gulf Medical University, UAE

    Biography
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    Biography

    Mohsen Khalid
    Gulf Medical University, UAE

    Mohsen Khalid has graduated from faculty of medicine Cairo University in November 1980. He has completed his Master degree in Internal Medicine May 1986, and then he completed his Medical Doctorate in Internal Medicine November 2003. He is a consultant of Diabetes and Endocrinology in the Egyptian National Institute of Diabetes and Endocrinology. He has published more than 20 papers in reputed journals. The research interest of Prof. Dr. Mohsen Khalid is Genetics of Diabetes, diabetic complications and how to assist diabetic patients to live a good life with life style modification and medical treatment.



    Abstract
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    Abstract

    Mohsen Khalid
    Gulf Medical University, UAE

    Background: Fractalkine (CX3CL1) is known to convey its signals through a single G protein coupled receptor (CX3CR1). It is characterized as a structurally unique chemokine with both membrane-bound and soluble forms. Fractalkine expression has been detected in activated or stressed endothelial, smooth muscle, skeletal muscle, macrophages, neurons, hepatocytes and adipocytes. Inflammation up regulates Fractalkine particularly in adipose tissue of obese individuals. Aim of Work: This study was designed to assess fractalkine level in obese subjects and its relation with some clinical and laboratory finding It compares basal plasma fractalkine and hs CRP in obese patients (with and without metabolic syndrome) and lean healthy controls. Subjects and Methods: The study was carried out on 140 subjects; 70 controls and 70 obese subjects 38 with metabolic syndrome and 32 without metabolic syndrome. All were subjected to full history taking, thorough clinical examination, fasting and post prandial blood glucose, HbA1c, lipid profile, fractalkine level and hs CRP. Results: Serum fractalkine level was significantly raised in obese subjects compared to lean controls (being higher in those with metabolic syndrome). There was a significant positive correlation between serum fractalkine level and BMI, WC, WHR, fasting and post prandial blood glucose, HBA1c, total cholesterol, triglycerides and LDL and it was inversely correlated with HDL while there was no significant correlation between serum fractalkine level and hs CRP. Conclusions: Fractalkine, like other known adipocyte derived chemokines was increased in obese individuals and associated mainly with metabolic syndrome. This is a step in the way to understand and explain the exact pathogenesis of metabolic syndrome as well as obesity linked complications.

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    Title: Physician and Patients Perspective to Weight Gain in Pregnanc

    Lorna Tate
    Mercy University Hospital, Ireland

    Biography
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    Biography

    Lorna Tate
    Mercy University Hospital, Ireland

    Lorna Tate graduated from University College Cork in 2017 with an Honours degree. She is currently working as a Junior Doctor in the Mercy University Hospital Cork. She has a special interest in Obstetrics and Gynaecology. She has completed research under Professor Richard Greene, Director of the National Perinatal Epidemiology Centre (NPEC) and Professor of Clinical Obstetrics, UCC



    Abstract
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    Abstract

    Lorna Tate
    Mercy University Hospital, Ireland

    Gaining weight outside of the Institute of Medicine guidelines puts a woman and her foetus at an increased risk. Currently, limited or incorrect information about weight management is being provided to women during antenatal care. Despite the global obesity epidemic, research shows that physicians do not perceive this to be an important issue. Women are not getting adequate advice about weight management in pregnancy. Aims: To assess what Irish women want regarding weight gain and the management of weight during pregnancy. To assess physician understanding and attitude to weight gain in pregnancy. To assess current weight management during the antenatal period. Methods:This was a quantitative cross-sectional study. There were two aspects to the data collection. Patient data was collected by printed questionnaires in the Cork University Maternity Hospital antenatal clinic; 100 first bookers completed the questionnaire. Physician data was collected via SurveyMonkey. Physical questionnaires were also used to gather physician data. Results:The majority of women (71%) want to be given a target weight to gain during pregnancy; 74% want to be told if they are inappropriately gaining weight. 91% want information about diet and exercise. 18% think discussing weight gain is sensitive and should be avoided. Some 87.5% of physicians believe that weight management is important; 31.3% advise patients about weight gain. 68.8% perceive discussing weight gain as a sensitive subject. Conclusion:Women want discussions about weight gain to be an integral part of their antenatal care. Physicians think weight management is an important part of antenatal care however they do not discuss it with patients, mainly because they feel it is a sensitive issue. More advice needs to be given to women regarding weight gain in pregnancy to prevent excess weight gain. Physicians would benefit from further education in this area to ensure they can provide accurate and up to date advice to women

  • Keynote Speaker

    Time:

    Title

    Title: Technology and the Praise of Idleness

    Cristiana Lucretia Pop
    Bucharest University of Economic Studies, Romania
    Biography
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    Biography

    Cristiana Lucretia Pop
    Bucharest University of Economic Studies, Romania

    Dr. Cristiana Lucretia Pop is Professor at the Bucharest Economic Studies University, Physical Education and Health Department. Her research interests include: overweight and obesity risk assessment, well-being, quality of life, and promoting physical activity and a healthy lifestyle. She is member of Romanian Agency for Quality Assurance in Higher Education, member of Romanian Athletic Federation (women commission) and has research collaboration with Romanian Academy, Anthropological Institute Research Center. She is Senior Editor and Editorial Board Member of several reviews in education, health and sport sciences domain.



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    Abstract

    Cristiana Lucretia Pop
    Bucharest University of Economic Studies, Romania

    The obesity etiology is complex, involving genetic, environmental, psycho-socio-cultural, neuro-endocrine and metabolic factors. The purpose of my presentation is to concentrate on the effect of technology such as the TVs and computer screens that shape our lives rhythm and bodies harmony. Technology doesnt just keep us seated in front of our desks or on sofas, but changes our eating habits, adding more weight than the lack of physical activity alone. For every 10 % increase in information communications technology investment as a share of gross capital formation, the obesity rate climbs 1.4 % on average. At the same time 1 percentage point increase in the number of physically active people can prevent a 0.2 percentage point rise in obesity. The cell phone use was negatively associated with cardio-respiratory fitness in a sample of college students, suggesting that cell phones use disrupt physical activity and encourages sedentary behavior. Bending the head forward and down in a hunched position over a device for typing or gaming causes a higher pressure in the spine. This pressure increases with every degree of head flexing. A hunch posture compresses the internal organs restricting their function and making the body appear heavier. The cumulative effect of multiple sedentary behaviors reduces total daily energy expenditure, explaining the context in which the prevalence of childhood overweight and obesity has increased worldwide in recent decades and continue to rise in an alarming path. The ultimate risk of heavy technology use is that it diminishes empathy by limiting how much people engage with one another, even in the same family or the same room. The use of intelligent phones bright side, which stimulates the people interest for physical activities, can be recording their heart rate, step counts and energy expenditure, among other applications, demonstrating increases in physical activity and fitness level.

    Sessions:
    Obesity Prevention and Control & Endocrinal Disorders and Diabetes & Childhood obesity & Surgical and Non-Surgical Treatments & Cardiovascular Diseases, Pulmonary Function, Allergy & Immunity

    Time:

    Title: Duodenal Resurfacing Procedure A Novel Approach for Type 2 Diabetes Management

    Mahir Kh. Jallo
    Gulf Medical University, UAE

    Biography
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    Biography

    Mahir Kh. Jallo
    Gulf Medical University, UAE

    Dr. Jallo is a Clinical Professor of Medicine and Consultant Endocrinologist in Gulf Medical University GMU in UAE & Faculty in the Canadian Academy of Natural Health. Granted his MBChB from Mosul Medical College in IRAQ, postgraduate Board Certification in Internal Medicine CABM (PhD Equivalent) from the Arab Board, Fellowship of the American College of Endocrinology FACE & certified with Diploma in Dyslipidemia from Boston University School of Medicine from USA . He was an Affiliated Faculty in the Department of Medicine, Mosul Medical College & Department of Clinical Pharmacy, Mosul College of Pharmacy in IRAQ till 2004. He is actively involved as an inviting speaker in many National & International conferences & CME programs. He is the organizer of the annual GMU Diabetes & Endocrinology Conference, and organizing committee member of many international conferences. Editor In Chief: Diabetes Digest from Iraq, Editorial Board Member & reviewer for many international Diabetes & Endocrinology journals, with many publications in medical periodicals and medical conferences abstract & Active Principle Investigator in many National & International Clinical studies. He is a member of many national & international medical societies & associations



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    Abstract

    Mahir Kh. Jallo
    Gulf Medical University, UAE

    Bariatric surgery has emerged as an effective intervention to treat obesity and its related co morbidities. For multitude of factors, access, insurance, patient fears, referrals and the procedures risks, only 1% of the eligible undergoes bariatric surgery. Considerable needs for effective nonsurgical treatment modalities are mandated. The minimally invasive novel endoscopic therapies with less morbidity could be the answer for many morbidly obese patients. Researches advocate the important role of the foregut in the regulation of glucose homeostasis & diabetes. A novel purely endoscopic catheter-based procedure that targets the duodenal mucosa had been developed by Fractyl Laboratories targeting the abnormal hypertrophy and hyperplasia and the alterations in the enteroendocrine cells of the foregut usually seen in patients with diabetes. This minimally invasive Duodenal Mucosal Resurfacing System DMR is known as Revita.Revita involves 2 main steps: First, creation of a protective barrier by lifting the sub mucosal space of the duodenum with endoscopic injection of saline and second, hydrothermal ablation (recirculation of hot water within a balloon tipped catheter) of the circumferential duodenal mucosa. This rejuvenation of the lining of the duodenum will change gut signaling in patients with metabolic diseases caused by insulin resistance. The early results with Revita DMR are quite encouraging, with well tolerated procedure, concerning safety, three instances of duodenal stenosis was reported, and treated using endoscopic balloon dilation.The 1st study involving 39 T2 DM who were failing oral medications, at 6 months, the treatment had improved glycemic control, with significant decrease in FBG, PPG, and HbA1c. The patients receiving DMR on a long segment (average 9.3 cm, n 28) compared to short (average 3.4 cm, n 11) of the duodenum experienced a greater reduction in HbA1c levels at 3 months and achieved a reduction in HbA1c levels from 8.5% to 7.1% at 6 months & about 5 pounds of weight loss. Further studies are necessary to understand the core mechanism, long-term safety, efficacy, durability and how the procedure performs in a randomized clinical trial setting, while also embracing the potential for wider metabolic benefits.

    Time:

    Title: The Biological Function of the Bioactive Peptide of Alpha-S2 Casein Goat Milk Prevent AGEs and RAGE Interaction in Cellular Mechanism

    Fatchiyah Fatchiyah
    Brawijaya University, Indonesia

    Biography
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    Biography

    Fatchiyah Fatchiyah
    Brawijaya University, Indonesia

    Prof. Fatchiyah F., PhD., is a professor of Molecular Genetics and has completed a PhD program at the Graduate University for Advances Studies, Department of Molecular Biomechanics, National Institute for Basic Biology, Okazaki, and Aichi, Japan, 2006. She is senior lecturer in molecular genetics at Biology Dept. Faculty of Sciences, Brawijaya University. Malang, Indonesia since 1989 till present; as director of Center Laboratory of Life Sciences, UB during 2007-2012; as director of Institute Biosains of UB, 2012-present, and as a head of Center Research of SMONAGENES UB focus on: Nutrigenomics study of Natural Genetics Resources, Molecular Biomechanics of Gene Cascade of Metabolic and Degenerative Diseases and Genes Mapping. Website: http://fatchiyah.lecture.ub.ac.id



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    Abstract

    Fatchiyah Fatchiyah
    Brawijaya University, Indonesia

    The interaction nutrients, lifestyles and genetic factor modulate molecular pathway in human related to developing chronic diseases. Healthy nutrients composition can reduce the incidence of cardiovascular, obesity, and type 2 diabetes mellitus diseases due to repairing abnormality molecular mechanism signaling. AGEs provide new possible targets for the treatment of both diabetes. Hyperglycemia is an abnormally high blood glucose (blood sugar) level. Among the irreversible changes that occur as a result of hyperglycemia is the formation of AGE through a reaction between sugars and the free amino groups on proteins, lipids, and nucleic acids. AGEs react with their receptors (RAGEs) to induce oxidative stress. Recent study, we found the local caprine milk CSN1S2 protein has eight peptide residues contain seven to twelve amino acid residues which are suggested to reveal multifunctional properties. The goals to be achieved in managing diabetes are prevention or control of pancreatic β-cells damage, prevention of loss of function, and reduction of complication. This study used 24 rats of control and diabetic models treated with CSN1S2of Caprine milk and then analyzed the physiological character, protein expression and in silico analysis. The study results showed that the body weight gaining and some organ weight reduced, the level of sRAGE up-regulated and AGE level down-regulated on DM-750mg/kg caprine milk compared with DM group. The fragment 41-47 of CSN1S2 has inhibitor activity of Argypirimidine-RAGE interaction. In other hand, CSN1S2 fragment 214-221 can also require the imidazole bind to arginine residue 221 of the peptide. These results indicated the possibility of Caprine CSN1S2 peptide able to take place biological function as a competitive inhibitor of AGEs and RAGE interaction that may intervenes its cellular mechanism and impaired signal transduction cascade at the cellular level.

    Time:

    Title: Serum C1q/TNF-related protein-3 (CTRP3) levels may be a potential future biomarker in obesitp

    Neha Bindlish Jain
    University College of Medical Sciences & Guru Teg Bahadur Hospital, India

    Biography
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    Biography

    Neha Bindlish Jain
    University College of Medical Sciences & Guru Teg Bahadur Hospital, India

    Dr. Neha Bindlish Jain was born in New Delhi, India, in 1984. After graduating from University College of Medical Sciences and Guru Teg Bahadur hospital, Delhi, in the year 2008, she is currently pursuing her MD Physiology from the same institution. She also underwent a short term training course in autonomic function tests from Department of Physiology, AIIMS, Delhi, for a better understanding of her current research interest. To the best of her knowledge, the current research on C1q/TNF Related Protein 3 (CTRP3) and obesity shall be the first one to be conducted in India. This current research is her gateway to pioneer in the field of Physiology



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    Abstract

    Neha Bindlish Jain
    University College of Medical Sciences & Guru Teg Bahadur Hospital, India

    Background- We hypothesized that higher circulating levels of a novel adipokine CTRP3, would promote a favorable metabolic profile in obesity. Objective- To study and correlate the circulating levels of serum CTRP3 and metabolic parameters in obesity. Design- A non- randomized case control study in a tertiary care hospital. Subjects & Methods- Sixty subjects were recruited from general population into the study and control groups, based on Body mass index (BMI as kg/m2). There were no drop outs. Newly diagnosed, drug naive obese subjects with BMI 25-35kg/m2 of both genders, aged 18-40yrs, with no associated co-morbidity or substance abuse, were grouped as CASES (n=30) and compared with age, sex and socioeconomic status matched CONTROLS (n=30) with BMI 19- 22kg/m2. The baseline fasting metabolic parameters (HbA1c, SBP, DBP and TSH) were within normal range in both the groups, thus excluding confounders for CTRP3 and obesity. Statistical analysis- Unpaired Students t-test and Pearsons correlations and linear regression using SPSS-20 software. Data was presented as mean SD. p 0.05 was considered significant. Results- We found lower levels of serum CTRP3(p<0.001), adiponectin(p=0.025), HDL(p<0.001), and higher BMI(p<0.001), leptin(p=0.04), insulin(p=0.003), HOMA-IR(p<0.001), LDL(p<0.05) and atherogenic index(p<0.001) in cases. Also, CTRP3 inversely correlated with serum triglycerides(p<0.001), atherogenic index(p=0.04), leptin(p=0.02), and positively with adiponectin(p=0.02) in obese group. Conclusions- Serum CTRP3 levels are lowered in obesity. This was probably the first study to show that CTRP3 levels are inversely correlated with the atherogenic index in obesity. Hence, in future, optimizing CTRP3 levels may prove as a potential therapeutic target to improve obesity and its co-morbidities. Key Words- C1q/TNF-Related Protein-3 (CTRP3), Body Mass Index (BMI), Obesity, Adiponectin, Leptin & Atherogenic Index.

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    Title: Anthocyanin-Rich Potato Improves Cardiovascular Risk Factors in Healthy Human Adults

    Catherine Tsang
    Edge Hill University, UK

    Biography
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    Biography

    Catherine Tsang
    Edge Hill University, UK

    Dr Tsang is a Senior Lecturer in Human Nutrition and Health at EHU (UK). Having obtained her Masters and Doctoral (PhD) training from the Medical Faculty and the Institute of Biomedical and Life Sciences at the University of Glasgow (UK), her research interest is in the area of Antioxidants and Health. She is particularly interested in the role of dietary phytochemicals and their potential as functional foods, in their ability to alleviate oxidative related conditions, including diabetes, cardiovascular disease (CVD), hypertension and obesity. She has also worked extensively on a wide range of funded projects on a consultancy basis and engages in knowledge exchange with partners in the Food and Drink industry in the UK. Currently, she is collaborating with senior academic research partners in the UK, France and the Middle East on research projects. Catherine has published several articles in peer-reviewed journals, book chapters and conference proceedings.She is also a Fellow of the Higher Education Academy (2016)and a recent fellow of the Royal Society of Medicine (2017)



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    Abstract

    Catherine Tsang
    Edge Hill University, UK

    Arterial stiffness is an emerging risk factor for cardiovascular disease (CVD), and dietary polyphenols, particularlyanthocyanins, may play an important role in mediating vascular tone. The present single-blind randomised cross-over placebo controlled study investigated the effect of consumption of an anthocyanin-rich potato, Purple Majesty (PM), in 14 healthy male and female adults. Participants consumed 200g PMcontaining 114 mg anthocyanins, or placebo (Osprey) with negligible anthocyanin content for 14 days, separated by a 1-week washout period. Non-invasive assessment of vascular tone (arterial stiffness) by pulse wave velocity (PWV) was determined in addition to systolic (SBP) and diastolic blood pressure (DBP),high density lipoproteins (HDL), low-density lipoproteins (LDL), triglycerides,glucose, insulin resistance (HOMA-IR) and c-reactive protein (CRP). Arterial stiffness was significantly reduced (p=0.001) following PM consumption. There were no significant changes with anyother clinical parameter measured, and no changes were observed following placebo.PM contained higher levels of total phenolics, total anthocyanins and antioxidant capacity and daily consumption of PM over 14 days was well tolerated by participants.The findings from this study suggest improved vascular tone following daily consumption of PM and inclusion in the diet could provide a rich and valuable source of anthocyanins.

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    Title: Gut Microbiota Profile in Obese and Non-Obese Minangkabau Adolescent Girls

    Ingrid S. Surono
    Bina Nusantara University, Indonesia

    Biography
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    Biography

    Ingrid S. Surono
    Bina Nusantara University, Indonesia

    Ingrid S.Surono has completed her Ph.D. at the age of 39 years from the United Graduate School of Agricultural Sciences, Japan, in 1996. She is an Assoc. Prof. at BINUS University, Jakarta. She serves as the President of Indonesian Scientific Society of Probiotics and Prebiotics (ISSPP), and as Advisory Council of Swedish South Asian Network (SASNET) Fermented Foods. She has published more than 20 papers in reputable journals and serving as an editorial board member of Microbiology and Immunology Journal. She supervised 6 Ph.D., and 3 Pediatrics. She has won Science and Technology Award in 2011 from Indonesia Toray Science Foundation (ITSF), and also was awarded as one of ten best researchers from RISTEKKALBE Science Award, organized by Ministry of State for Research and Technology, Indonesia and KALBE industry.



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    Abstract

    Ingrid S. Surono
    Bina Nusantara University, Indonesia

    Minangkabau ethnic people have particular dietary patterns with higher fat intake as compared to other ethnic groups in Indonesia. Fifty one teenager girls (aged 12- 15 years) were recruited from four regencies in West Sumatera and divided into two groups: obese (n= 26) and non-obese (n=25), and their stools were assessed by NGS for the profile of gut microbiota. In obese teenagers, Firmicutes and Firmicutes/Bacteroides ratio tended to be higher, Prevotella (Bacteroidetes) and Mitsuokella (Firmicutes) were significantly higher, (p=0.049) and (p=0.048), respectively, while Proteobacteria was significantly lower (p=0.045) as compared to non obese teenager girls, with Enterobacteriaceae and Klebsiella as predominant bacteria. Prevotella was the predominant genera in Bacteroidetes phylum, whereas Ruminococceae and Feacallibacterium were the most dominant genera in Firmicutes phylum. Keywords: gut microbiota, NGS, obese, non obese, teenager girls, Minangkabau ethnic

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    Title: Myocardial Metabolic Adaptation and Maladaptation to Obesity: Role of Apelin

    Kunduzova O
    National Institute of Health and Medical Research, France

    Biography
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    Biography

    Kunduzova O
    National Institute of Health and Medical Research, France



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    Abstract

    Kunduzova O
    National Institute of Health and Medical Research, France

    Background/Objectives: Altered energy metabolism is the defining characteristic of obesity-related myocardial damage. The adipocyte-derived peptide apelin has a role in the regulation of cardiovascular and metabolic homeostasis and may contribute to the link between obesity, energy metabolism and cardiac function. Here we investigate the role of apelin in the transition from metabolic adaptation to maladaptation of the heart in obese state. Methods: Adult male C57BL/6J, apelin knock-out (KO) or wild-type mice were fed a high-fat diet (HFD) for 18 weeks. To induce heart failure, mice were subjected to pressure overload after 18 weeks of HFD. Long-term effects of apelin on fatty acid (FA) oxidation, glucose metabolism, cardiac function and mitochondrial changes were evaluated in HFD-fed mice after 4 weeks of pressure overload. Cardiomyocytes from HFD-fed mice were isolated for analysis of metabolic responses. Results: In HFD-fed mice, pressure overload-induced transition from hypertrophy to heart failure is associated with reduced FA utilization (P<0.05), accelerated glucose oxidation (P<0.05) and mitochondrial damage. Treatment of HFD-fed mice with apelin for 4 weeks prevented pressure overload-induced decline in FA metabolism (P<0.05) and mitochondrial defects. Furthermore, apelin treatment lowered fasting plasma glucose (P<0.01), improved glucose tolerance (P<0.05) and preserved cardiac function (P<0.05) in HFD-fed mice subjected to pressure overload. In apelin KO HFD-fed mice, spontaneous cardiac dysfunction is associated with reduced FA oxidation (P<0.001) and increased glucose oxidation (P<0.05). In isolated cardiomyocytes, apelin stimulated FA oxidation in a dose-dependent manner and this effect was prevented by small interfering RNA sirtuin 3 knockdown. Conclusions: These data suggest that obesity-related decline in cardiac function is associated with defective myocardial energy metabolism and mitochondrial abnormalities. Furthermore, our work points for therapeutic potential of apelin to prevent myocardial metabolic abnormalities in heart failure paired with obesity

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    Title: Cortisol and Folate and their Roles in Alzheimers Disease, Diabetes

    Amos Gelbard
    Zefat Academic College, Israel

    Biography
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    Biography

    Amos Gelbard
    Zefat Academic College, Israel

    Amos Gelbard, a theology student in the Zefat Academic College Misticism and Spirituality program in Zefat, Israel. Has written more than a dozen papers suggesting possible cures and treatments to several key diseases. Been to the 2017 Health Conference in Oxford, England, where he presented his idea of possibly treating Malaria by excessive water drinking.Also written about Cancer where he suggested Zinc as a possible treatment; On Aids regarding Castanospermine as an important research target; Regarding Sclerosis possibly being a result of Vitamin D deficiency; Migraine Headaches being potentially prevented by more spicy food in nutrition and of several other illnesses. Lives in Kibbutz Eilon in the Israeli Western Galillee, near the Sea and the Lebanese Border



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    Abstract

    Amos Gelbard
    Zefat Academic College, Israel

    Abstract: In previous articles[1-2,4], I studied the role of Cortisol, the stress hormone, produced to promote transfusion of sugar to the bloodstream in stressful situations, as the cause for Alzheimers Disease, based on the deteriorating effect it has on alpha, beta and gamma secretase, enzymes in charge of the peptide of amyloid beta.[1] I hypothesized that one way to downplay Cortisol secretion is by elevating blood glucose levels in nutrition[1], but this was challenged by Alzheimers occurrence in Type2 Diabetes Patients[2]. In this 2nd article I hypothesized that Insulin treatment could be the reason for this malice. This based on the logic that the body could be responding to Insulin infusion - the hormone in charge of sugar transfusion from the bloodstream to the body - with elevated Cortisol secretion, because it has impact similar to glucagon, the hormone opposite to Insulin. This proved to possibly be true[3]. I also brought evidence that Glucagon having Cortisol like effect thus possibly be making it redundant could be why GLP1 (Glucagon Like Peptide) has been researched with very good results as AD treatment[2] and that diabetics on noninsulin diabetes medications were shown to be having lower AD occurrence.[2]. In the following paper[4] I argued that Diabetes type 2 should not be treated with Insulin or at all, but that Diabetes’ hallmark of sugar in the urine, is the bodys natural way of treating the disease. I concluded the paper by suggesting that medical intervention to diabetes should only be done by advocating Sports or Diet[4]. I later pondered a conclusion that diabetes could be in some ways a behavioral reaction to high Cortisol levels, for the same logic of answering Cortisol secretion with Glucosic nutrition[1] which also proved to possibly have some merit[5]. And when I tried to think what could cure high Cortisol Levels, not by duplication of its role, but by itself, I thought of Folic Acid, for the soothing effect of leaves.[6] and indeed, Several studies show low folate levels and not just high cortisol levels as correlated with Alzheimers.[6-10] This, by the way, could also be true for Cushing Syndrome[11] and Schizophrenia[12], where high cortisol levels and low folate levels are evidenced. And could also be true for Diabetics if high Cortisol levels are indeed related to the development of Diabetes [5,13,14].

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    Title: Laparoscopic Gastric Plication; Why We Stopped Doing It

    Ahmed Elgeidie
    Mansoura University, Egypt

    Biography
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    Biography

    Ahmed Elgeidie
    Mansoura University, Egypt



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    Abstract

    Ahmed Elgeidie
    Mansoura University, Egypt

    Background: Laparoscopic gastric plication (LGP) is one of the restrictive bariatric procedures. It seemed attractive to both morbidly obese patients and bariatric surgeons due to two main factors; safety and low cost. Moreover, many studies documented its efficacy in terms of weight loss and resolution of comorbidities. This study tests the mid-term outcome of LGP in morbidly obese patients. Patients and methods. The data of morbidly obese patients who underwent LGP were analyzed. LGP was offered to obese patients with BMI > 40 kg/m2 or > 35 kg/m2 with one or more comorbidities. Superobese patients (BMI > 60 kg/m2) and those who have previous bariatric surgeries were excluded. The technique of LGP was standardized. After gastric mobilization the stomach was plicated in two rows of extramucosal non-absorbable sutures over 36 Fr calibrating tube. Perioperative and in-hospital data were recorded. Postoperative follow up visits was scheduled at 1, 3, 6, 12 months then annually. Patients were followed for complications, weight loss and resolution/improvement of comorbidities. Results. Eighty eight consecutive morbidly obese patients had been operated by the standardized technique of LGP between March 2010 and September 2014. There were 19 men and 69 women, with a mean age of 24.2 years and a mean BMI of 38.7 kg/m2 (range 35 to 51 kg/m2). Type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, and back pain were reported in 4, 10, 12, 4, 6 patients respectively. There were no significant intraoperative complications and no conversion to laparotomy. The most frequently reported complication was prolonged early postoperative nausea/vomiting and occurred in 5 of 88 (5.7) patients and were treated with conservative means. Early leak occurred in 3/88 (3.4%) patients and it was managed by conversion to laparoscopic sleeve gastrectomy (LSG) in two patients (one of them died of sepsis) and suture repair with undoing plication in the last patient. Postoperative follow-up period ranged from 6 to 42 months with a mean of 25 months. EWL was 27.2 %, 35.0 %, and 41.1 % at 3, 6, and 12 months, respectively. Weight regain had been reported in 10 (11.4%) patients at a mean follow up period of 9.5 months. It was treated by laparoscopic replication (n=2), conversion to LSG (n=1), laparoscopic minigastric bypass (MGB) (n=1). One of replicated patients had inadequate weight loss and was converted to laparoscopic MGB. Resolution/improvement of comorbidities was documented in 5/36 (13.9%) patients only. Conclusions: Inadequate weight loss, prolonged hospital stay, inadequate resolution/improvement of comorbidities plus risk of leak forced us to stop LGP. However, more studies on a larger number of patients with longer follow up is required.

    Time:

    Title: Prevalence of Hyper Insulinism, Type2 Diabetes Mellitus and Metabolic Syndrome among Saudi Overweight and Obese Pediatric Patients

    Abdulmoein Al Agha
    King Abdul Aziz University, Saudi Arabia

    Biography
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    Biography

    Abdulmoein Al Agha
    King Abdul Aziz University, Saudi Arabia

    Abdulmoein Al Agha is a Professor of Pediatrics & Pediatric Endocrinology at King Abdul Aziz University. He received his Fellowship certificate in Pediatric Endocrinology and Diabetes from Sydney, Australia, 2001. Fellowship of the Royal College of Physician (Edinburg) since 1997, and graduated King Abdul Aziz University Medical School, Jeddah, Saudi Arabia, 1991. He has many present and past academic and administrative positions including; MRCPCH Overseas examiner and host as well supervisor for Saudi Board Pediatric residency training for western Region since 2001. He is a coordinator, Pediatric Club Western Region, since 2007 to present. He is the chairman of Reproductive Modules "New Faculty Curriculum" from 2009 to present. He was acting Chairman, of Pediatric, KAUH 2006-2007. He is as well, a visiting instructor and teacher, Ibn- Sina Medical School, 2008 to present. He has been invited to be an external examiner for many of Gulf and Arab countries; including Bahrain, Kuwait, United Arab Emirates, Oman, and Egypt for Pediatric under and post graduates as well for Endocrine examinations. He has been invited as speaker for many of local educational programs and conferences as well Gulf, Arab and international conferences. He developed interest in medical education and he had Certificate of medical education- university of Illinois, Chicago, USA 2009. In research he has published more than 40 publications in refereed journals and orally presented more than 60 presentations in international meetings. He has also authored an English textbook of Pediatric Endocrinology and diabetes textbook, and 10 Arabic books. Finally, he is a member of many of Pediatric and Endocrine local and international societies.



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    Abstract

    Abdulmoein Al Agha
    King Abdul Aziz University, Saudi Arabia

    Obesity and overweight among children and adolescents is increasing at an alarming rate, which lead to the increase in the incidence of their related co-morbidities. Our objectives are to establish the following: 1) the prevalence of hyperinsulinism among overweight and obese pediatric patients. 2) The prevalence of type 2 diabetes mellitus (T2DM) among those with hyperinsulinism. 3) The prevalence of metabolic syndrome (MS) and its components among T2DM pediatric patients. A retrospective cross-sectional study conducted on overweight and obese pediatric patients attending the pediatrics diabetes clinic at King Abdul-Aziz University Hospital, Jeddah, Saudi Arabia, from 2006 to 2010. Serum insulin level was measured for 387 patients (ages from 2 to 18 years). Those with hyperinsulinism underwent further investigations to assess the prevalence of T2DM and the prevalence of MS among T2DM patients. The overall prevalence of hyperinsulinism and T2DM were 44.7%, and 9.04%, respectively. Among children and adolescents with T2DM, 62.86% had a body mass index BMI≥85th percentile, 37.14% had a BMI ≥ 95th percentile, 14.29% had MS, 34.29% were hypertensive and 28.57% had dyslipidemia. Obesity and its co-morbidities were prevalent among Saudi pediatric patients. We recommend preventing excessive weight gain through the promotion of a healthy lifestyle, family educational seminars and the reinforcement of indoor exercises

    Sessions:
    Poster

    Time:

    Title: Severe Diabetic ketoacidosis in a Newly Diagnosed Child with Type 2 Diabetes Mellitus

    Mohammed AlAgha
    King Abdulaziz University, Saudi Arabia

    Biography
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    Biography

    Mohammed AlAgha
    King Abdulaziz University, Saudi Arabia

    Mohammed AlAgha is a senior medical student at King Abdulaziz University, Jeddah, Saudi Arabia. Currently he is in the internship year and he is enjoying his last eleven months left for him before graduation. During his 6 years in medical school, he had an outstanding performance, and has maintained his positionat the top of the deans list for the top ten students. He has started his journey of research by two researches, and has previously presented one of them in a conference held in Jeddah, 2016



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    Abstract

    Mohammed AlAgha
    King Abdulaziz University, Saudi Arabia

    Background: Diabetic ketoacidosis (DKA) is an acute complication of both type 1 and type 2 diabetes mellitus (DM). DKA is characterized by the presence of hyperglycemia, ketosis, ketonuria, and metabolic acidosis. Cerebral edema is a rare but rather a serious complication of DKA. Case presentation: An obese 12-year-old, Egyptian boy, previously medically free, presented to the emergency room (ER) of King Abdulaziz university hospital, with two weeks' histories of dizziness, shortness of breath, polyuria, polydipsia &nocturia. His symptoms were deteriorating with a change in sensorial and cognitive functions at the time of presentation. He was diagnosed with type 2 DM based upon clinical background, namely the presence of obesity (weight+7.57 Standard Deviation Score (SDS), height+1.4 SDS, and body mass index (BMI) of 34.77 kg/m2 (+3.97SDS) together with the presence of Acanthosisnigricans and biochemically based on, normal level of serum insulin, normal serum level of connecting peptide and negative autoantibodies. He was presented with severe DKA, based on clinical and laboratory criteria. During the first 12 h of hospitalization, the patient has developed cerebral edema based upon clinical and radiological bases with the requirement of intensive therapeutically managements with final complete clinical, biochemical and radiological recovery. The patient was discharged home on oral metformin therapy after gradual weaning from insulin therapy, which was needed initially during his acute presentation. We aimed to present a rare presentation of severe DKA with cerebral edema in a child with Type 2 DM. Conclusion: Despite type 1 DM is the commonest type of diabetes in children, pediatricians should be aware of other types of diabetes, particularly type 2, as the prevalence of obesity in children is increasing. Children with type 2 DM are also prone to develop DKA, thus proper and rapid investigations to diagnose DKA in suspected patients are mandatory. Those patients are also at risk to develop cerebral edema, thus proper monitoring for neurological symptoms during the management of DKA is crucial.

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    Title: Effects of Germinated Soy Germ Extract on Obesity

    Eun-ji Choi
    Konkuk University, Korea

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    Biography

    Eun-ji Choi
    Konkuk University, Korea

    Eun-ji Choi received the B.S. degree from the College of Veterinary Medicine, Konkuk University, Korea, in 2016. She is currently a Ph.D. course in Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University. Her research interests include obesity, osteoporosis, and arthritis and tumor immunotherapy.



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    Abstract

    Eun-ji Choi
    Konkuk University, Korea

    Obesity is a worldwide public health concern asking for safe dietary strategies. Recent studies suggest that isoflavones from soy or soybeans have beneficial effects on weight loss and reducing fat accumulation. However, the effects of germinated soy germ are not fully investigated, despite the biochemical and nutritional changes during germination.In our study, we aim to evaluate the effects of germinated soy germ extracts (GSGE) on obesity. High-fat diet (HFD) induced obese C57BL/6 were randomly assigned to four groups: (i) HFD: HFD only; (ii) Low: HFD and 1mg/kg of GSGE; (iii) Mid: HFD and 5mg/kg of GSGE; (iv) High: HFD and 20mg/kg of GSGE. The mice received GSGE by intragastric administration for 5 weeks daily andwere assessed for body weight, wet fat weight, micro-CT analysis and histological analysis.All the GSGE treated groups showed decrease in average body weight, gonadal fat weight and adipose tissue volume at 5 weeks. In addition, the average size of adipocytes in subcutaneous and visceral adipose tissues was significantly reduced. Moreover. the expression of genes associated with the adipogenesis and lipogenesis was downregulated in GSGE treated groups. These results demonstrate that germinated soy germ extract has potential to promote weight loss and reduce fat accumulation, being a promising dietary strategy for preventing obesity.

    Time:

    Title: Ceruloplasmin and its Clinical Relevance as Predictor for Metabolic Syndrome and Risk of Future Cardiovascular Disease in Adolescents

    Angel Fernandez-Aparicio
    Granada University, Spain

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    Biography

    Angel Fernandez-Aparicio
    Granada University, Spain

    Currently, I am a researcher at Granada University, Granada, Spain. Recently, I finished my nursing studies in 2015, and in this year I am going to start a master entitled Health Care for the Promotion of the Peoples Autonomy and the Attention to the Processes of the End of Life.



    Abstract
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    Abstract

    Angel Fernandez-Aparicio
    Granada University, Spain

    Introduction: The metabolic syndrome (MetS) is defined in adults as a set of risk factors of metabolic precursors of atherosclerotic cardiovascular disease and type 2 diabetes mellitus (DM2). However, data on children and adolescents are still scarce, in part, because of difficulties in transposing the definition from adults. The identification of risk factors for the development of MetS at an early age is essential for prevention purposes with lowgrade inflammation acting as a determinant for the association among the MetS components. The aim of this study was to investigate the associations of the MetS with systemic markers of inflammation and ceruloplasmin in a population of adolescents. Methods: A crosssectional study performed on 976 adolescents (13.2 1.2 y) randomly recruited from schools in south east Spain. Interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α) were determined by ELISA. High sensitivity C reactive protein (hs-CRP) was determined by a solid-phase chemiluminiscentimmunometric assay. Ceruloplasmin was measured by immunoturbidimetry. Results: Mets adolescents exhibited higher levels of TNF α, IL 6, CRP, and ceruloplasmin compared to non MetS individuals. TNF-α, IL 6, and CRP showed strong correlations with the MetS components and insulin resistance but not relevant predictive values according to ROC curves (AUC values 0.544- 0.555). In contrast, ceruloplasmin only showed significant correlations in non Mets individuals, but exhibited a very high predictive value (AUC=0.941, P < 0.001). Conclusions: Ceruloplasmin have an elevated predicted value for MetS in adolescents. The determination of serum ceruloplasmin in adolescents might be a useful tool to identify patients with the highest risk of future cardiovascular disease.

    Time:

    Title: Metabolic and Anti-Inflamatory effects of Oleanolic Acid in Obese Subjects

    Angel Fernandez-Aparicio
    Granada University, Spain

    Biography
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    Biography

    Angel Fernandez-Aparicio
    Granada University, Spain

    Currently, I am a researcher at Granada University, Granada, Spain. Recently, I finished my nursing studies in 2015, and in this year I am going to start a master entitled Health Care for the Promotion of the Peoples Autonomy and the Attention to the Processes of the End of Life.



    Abstract
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    Abstract

    Angel Fernandez-Aparicio
    Granada University, Spain

    Introduction: Obesity is a risk factor for the development of insulin resistance. In addition, different studies indicate that obesity is an inflammatory disorder; however, the mechanisms that link inflammation with obesity remain unclear. The objective of this study was to investigate the metabolic and anti-inflammatory properties of Oleanolic Acid (OA) in obese subjects. Methods: A systematic review was performed following PRISMA recommendations. The Medline and Web of Science databases were consulted, considering articles published in English in the last five years (2012-2017). We used the search equations: Oleanolic acid AND Obesity, Oleanolic acid AND Metabolic syndrome, and Oleanolic acid AND Insulin resistance, obtaining a total of 193 results, of which 28 articles were selected. Results: In animal models, administration of OA produced an improvement in blood lipid levels, reducing the concentration of free fatty acids and increasing levels of HDL-cholesterol. Also, it has been reported a significant reduction of the surface area of adipocytes. A serum decrease of Interleukin-6 and tumor necrosis factor alpha was found. In studies with 3T3-L1 cells, a decrease in leptin levels, a suppression in resistin synthesis, and increased secretion of adiponectin were observed. Conclusions: OA improves the lipid profile in obese subjects, particularly reducing the serum concentrations of free fatty acids. Its modulatory capacity on signaling molecules and pathways reduces subclinical inflammation associated with obesity. However, broader studies are needed in this field, especially in humans.

    Time:

    Title: The impact of a combined aerobic and resistance exercise programme in preventing or delay to the onset of diabetes for subjects at risk

    Bandar Manawer al Harbi
    De Montfort University, UK

    Biography
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    Biography

    Bandar Manawer al Harbi
    De Montfort University, UK

    Bandar Manawer al Harbi completed his Master of Science With Merit Pharmaceutical Quality by Design. Currently he is working as a Assistant Director of Pharmacy for Material Management Prince Sultan Military Medical City.



    Abstract
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    Abstract

    Bandar Manawer al Harbi
    De Montfort University, UK

    Pre diabetes describes a condition whereby an individuals level of blood glucose is above normal level, though not high enough to warrant them a T2D diagnosis. The condition is classified into two categories, impaired glucose tolerance (IGT) where blood glucose levels are above the normal 2 hours after glucose loading in the oral glucose tolerance test but not so high to warrant the classification as diabetes. The other is impaired fasting glucose (IFG) where blood glucose have risen to a fasting state but yet again, not so high to warrant the classification as diabetes. Physical exercise improves BG homeostasis but the extent to which exercise is effective strategy as primary prevention mechanism for people whom at risk to develop diabetes is not fully understood. Purpose: To examine the effects of 6 weeks moderate intensity combined aerobic and resistance exercise program in preventing or delaying the onset of diabetes for subjects at risk compared to sedentary non diabetic individuals. Methods: 20 subjects of a sedentary lifestyle, diagnosed with either pre diabetes or at risk to developed T2D (PRE-D) and 5 Subjects were sedentary healthy individuals (ND) met the inclusion criteria. Both PRE-D and ND have been asked to complete 6 weeks of moderate intensity combined aerobic and resistance exercise for 60 minutes on two days or week. Each exercise session consists of a combined exercise protocol of 30 minutes of resistance exercise (3 sets of 10 repetitions) followed by 20 min cycling. The primary outcome is to concentrate on metabolic results, such as improved HbA1c, blood pressure, heart rate, 1 repition max, lipid profile (reduction in Total Cholesterol, Low Density Lipoproteins, Triglycerides or increase High Density Lipoproteins) and improvements in insulin sensitivity determined by responses to oral glucose tolerance tests on independent days. Results: There were significant reduction (p=0.00) on the HbA1c after applying of 6 weeks combination exercise intervention in both groups comparing to baseline. OGTT indicated significant differences between Pre Exercise & Post 12th exercise session in both groups with p=0.01. BG concentrations were reduced post each exercise session and was significant Post EX S12 comparing PRE EX to P= 0.00 and P=0.09 in PRE-D and ND respectively. A significant reduction in TC (P=0.04) and LDL (P=0.02) in PRE-D only. SBP drops from 127.3 13.1 to 119.6 8.4 mmHg with P=0.04 in PRE-D while in ND was not significant. HR was significantly reduced (P=0.01) and goes from 73.5 10.3 to 70.3 12.1 in PRE D and was significantly reduced (P=0.03). A significant reduction in RPE have been achieved with P=0.00 in PRE D and P=0.03 in ND group 1RM improved significant in back (P=0.04) and triceps (P=0.04) in PRE D, while in ND group the significant improvement was in squat (P=0.02) and back (P=0.02). Conclusion: A combination exercise programs, which involves both RE, and AE performed at moderate intensity (50 to 60% of 1RM) over 6 weeks period can be feasible and economical prevention strategies to minimize the risk factors for T2D in prediabetes subjects

    Time:

    Title: Physician and Patients Perspective to Weight Gain in Pregnancy

    Tate L
    Mercy University Hospital, Ireland

    Biography
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    Biography

    Tate L
    Mercy University Hospital, Ireland

    Lorna Tate graduated from University College Cork in 2017 with an Honours degree. She is currently working as a Junior Doctor in the Mercy University Hospital Cork. She has a special interest in Obstetrics and Gynaecology. She has completed research under Professor Richard Greene, Director of the National Perinatal Epidemiology Centre (NPEC) and Professor of Clinical Obstetrics, UCC.



    Abstract
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    Abstract

    Tate L
    Mercy University Hospital, Ireland

    Introduction: Gaining weight outside of the Institute of Medicine guidelines puts a woman and her foetus at an increased risk. Currently, limited or incorrect information about weight management is being provided to women during antenatal care. Despite the global obesity epidemic, research shows that physicians do not perceive this to be an important issue. Women are not getting adequate advice about weight management in pregnancy. Aims: To assess what Irish women want regarding weight gain and the management of weight during pregnancy. To assess physician understanding and attitude to weight gain in pregnancy. To assess current weight management during the antenatal period. Methods: This was a quantitative cross-sectional study. There were two aspects to the data collection. Patient data was collected by printed questionnaires in the Cork University Maternity Hospital antenatal clinic; 100 first bookers completed the questionnaire. Physician data was collected via SurveyMonkey. Physical questionnaires were also used to gather physician data. Results: The majority of women (71%) want to be given a target weight to gain during pregnancy; 74% want to be told if they are inappropriately gaining weight. 91% want information about diet and exercise. 18% think discussing weight gain is sensitive and should be avoided. Some 87.5% of physicians believe that weight management is important; 31.3% advise patients about weight gain. 68.8% perceive discussing weight gain as a sensitive subject. Conclusion: Women want discussions about weight gain to be an integral part of their antenatal care. Physicians think weight management is an important part of antenatal care however they do not discuss it with patients, mainly because they feel it is a sensitive issue. More advice needs to be given to women regarding weight gain in pregnancy to prevent excess weight gain. Physicians would benefit from further education in this area to ensure they can provide accurate and up to date advice to women

    Time:

    Title: Lower Mechanical Sensitivity in Female Obese Model Following Oral Probiotic Supplementation

    Fereshteh Dardmeh
    Aalborg University, Denmark

    Biography
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    Biography

    Fereshteh Dardmeh
    Aalborg University, Denmark

    Fereshteh Dardmeh graduated as a Doctor of Veterinary Medicine (D.V.M.) from Urmia University, Iran in 2012. She then joined the Laboratory of Reproductive medicine and Center for Sensory-Motor Interaction (SMI) in the Department of Health, Science and technology of Aalborg University, Denmark and got the PhD degree in 2017. She has since been actively involved in teaching and research in the area of reproductive health and medicine with her current studies focusing on Probiotic supplements as a novel strategy in pain management and translational investigations of possible associations between pain, obesity and fertility. Her studies have until now resulted in several abstracts and publication



    Abstract
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    Abstract

    Fereshteh Dardmeh
    Aalborg University, Denmark

    Background: Obesity is one of the most obvious appearances of the worldwide epidemic of sedentary lifestyles and excessive energy intake. A lower pain threshold has been proved in obesity both in animals and humans. Among the endogenous factors prompting the obesity, intestinal microbiota has also been proposed to influence pain sensitivity. Probiotics have shown beneficial effects on obesity, but data on their analgesic efficacy is very limited. Hence, this study aimed at investigating effect of oral probiotics on pain sensitivity in female obese mice. Methods: Six-week old female C57BL/B6 F mice were fed with a high fat diet (week 1 to 4) to make DIO (diet induced obesity) mice. The DIO mice were then randomly assigned to 2 groups treated with a single daily dose (1x109CFU) of Lactobacillus Rhamnosus (test group) or physiological saline (control group) for 4 weeks (weeks 5 to 8). Sensitivity to mechanical stimulation was assessed by an electronic Von Frey every two weeks throughout the study period. Results: The DIO mice in the test group did not show a significant gain weight after the start of probiotic administration. However the control group maintained a weight rising trend leading to a significant weight difference at week 6, which remained significant at week 8. The test group showed a trend of lower pain sensitivity to mechanical stimulation compared with the control group after two weeks of receiving the probiotic treatment (P 0.01). After 4 weeks of probiotic administration, mice fed with probiotics having a significant less pain sensitivity. (P 0.01) Conclusion: The results of this study confirmed lower mechanical pain sensitivity in probiotic treated female obese mice. The protective effect of probiotics on nociception circuits could be associated with the weight reduction or anti inflammatory properties of the probiotics. Translation of this result in humans can potentially suggest a novel therapeutic strategy in pain management of obese individuals

    Time:

    Title: What is the Quality of Systematic Reviews/Meta-Analyses Published in the Field of Bariatrics Preliminary Results of Cross Sectional Systematic Survey

    Monika Storman
    Jagiellonian University, Poland

    Biography
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    Biography

    Monika Storman
    Jagiellonian University, Poland

    Monika Storman, a PhD candidate at Department of Internal Medicine and Diabetology, Medical University of Warsaw, graduated from Jagiellonian University Medical College, Krakow, Poland



    Abstract
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    Abstract

    Monika Storman
    Jagiellonian University, Poland

    Background: Bariatric surgery is the one of the main treatments of morbidly obese patients. Despite an enormous growth in the number of published systematic reviews (SR) and metaanalyses (MA) in the field of bariatrics, no research on the quality of such studies published have been reported so far. Objectives: To assess the quality of studies published as SR or MA, which were published since the beginning of 2016 and to compare the quality of such studies published in 2016 to 2017. Methods: We searched for the studies in electronic databases using specially designed search strategy with no language restrictions. Our inclusion criteria for this pilot sub-analysis were SA and MA, which compared current bariatric surgery with any surgical or non-surgical control. Two authors independently reviewed all titles and abstracts and assessed the full text of potentially eligible studies and assessed the quality of included studies. The quality of each SR and MA was scored using the AMSTAR checklist. Results: Out of 638 identified papers we finally included 23 papers with a control group. Studies published in 2017 scored higher in AMSTAR checklist than in 2016 (mean 4.67 vs 4.0). In 2016 majority of SR and MA were of low quality (<5 points; 71.43%), in 2017 medium (>=5 points; 55.56%). In 2016 to 2017 item formulating conclusions was most frequently scoring 0 (70.83%). Score 1 was most frequently observed for the items: study characteristics (95.83%) and search strategy (75.0%). In AMSTAR the item publication bias scored 1 in just 45.83% of study. Conclusions: Although the quality of studies published as SR and MA in 2016 improved as compared to those published in 2017, it is still unsatisfactory. We highly recommend that journal editors and peer reviewers pay more attention to the methodological quality of accepted SR and MA.

    Time:

    Title: Exercises Before and After Laparoscopic Sleeve Gastrectomy and Laparoscopic Roux-en-Y Gastric Bypass

    Katarzyna Jasińska
    Jagiellonian University, Poland

    Biography
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    Biography

    Katarzyna Jasińska
    Jagiellonian University, Poland

    Beginning researcher from Faculty of Medicine, Jagiellonian University Medical College, Poland. Member of Students Scientific Group at 2nd Department of General Surgery and Students Scientific Group of Systematic Reviews.



    Abstract
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    Abstract

    Katarzyna Jasińska
    Jagiellonian University, Poland

    Introduction: Laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux en Y gastric bypass (LRYGB) are proven as effective long term weight loss procedures. However, it remains still unclear whether bariatric surgery influences physical activity. Aim: To assess exercises changes after laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass. Materials and methods: This prospective observational study was conducted from 2015 to 2016 at 2nd Department of General Surgery Jagiellonian University in Cracow, Poland. Inclusion criteria were: age 18-65 y.o., positive qualifiaction to bariatric surgery and consent of participation into this trial. Physical acitivity was measured in metabolic equivalent of task per minute (MET minutes) by two validated tools: Paffenbarger Physical Activity Questionnaire and WHO Global Physical Activity Questionnaire before the procedure and at 12 month follow-up. Results: 54 patients met the inclusion criteria. 24 of them were males (44.44%). Mean age of participants was 43.6 12.2y.o. And mean BMI was 45.94 6.35kg/m2. 44 patients (81.48%) have had at least one obesity - related co morbidity. Mostly performed procedure was LSG (n=37, 71.15%). Follow up measurement was successful in 40 participants (74.07%). 12 months after surgery MET minutes has changed from Me:299.75, Q1-Q3:225.78-358.38 to Me:4339.85, Q1 to Q3:1590.6 to 7827.1, p<0.0001. Daily sitting or reclining time has reduced from 480 to 300 min. (p=0.0012). Exertion during normal activities, measured at VAS, has decreased from mean 5 (strong effort) to mean 2.5 (light effort) (p=0.00004). No correlation between changes in BMI and MET minutes was observed (R=0.0634, p=0.7302). Conclusions: This trial shows notable exercises level increase 12 months after bariatric surgery. A further investigation is needed to develop post surgical guidelines and interventions.

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